CADM2_HUMAN » Cell adhesion molecule 2

CADM2_HUMAN » Cell adhesion molecule 2
Magnify CADM2_HUMAN » Cell adhesion molecule 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADM2_HUMAN » Cell adhesion molecule 2 » Immunoglobulin superfamily member 4D;IgSF4D; Nectin-like protein 3;NECL-3; Synaptic cell adhesion molecule 2;SynCAM 2;
Hydrophobic Thickness 35.2 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -47.4 kcal/mol
ΔGfold -18.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 365-393 (365-395)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes

CADM2:CADM2_MOUSE

Interactions

CADM2, Complex: Homodimer of cell adhesion molecule 2, PDBID: 3M45

Domains

AA: 28-121, PDBID: 3M45, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 125-213, PDBID: 4OFD, Subunit B, Seq Identity:33%, CD80-like C2-set immunoglobulin domain

AA: 226-300, PDBID: 1CS6, Subunit A, Seq Identity:38%, Immunoglobulin domain

UniProt annotation for CADM2_HUMAN » Cell adhesion molecule 2
FUNCTION: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
UniProt features for CADM2_HUMAN » Cell adhesion molecule 2
SIGNAL 1 24 Potential.
CHAIN 25 435 Cell adhesion molecule 2.
DOMAIN 27 119 Ig-like V-type.
DOMAIN 127 219 Ig-like C2-type 1.
DOMAIN 227 312 Ig-like C2-type 2.
DISULFID 44 104 By similarity.
DISULFID 146 203 By similarity.
DISULFID 248 296 By similarity.
Amino Acid Sequence for CADM2_HUMAN » Cell adhesion molecule 2
MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQPLILTCES KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT SSIRDPNALA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI