CADM1_HUMAN » Cell adhesion molecule 1

CADM1_HUMAN » Cell adhesion molecule 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADM1_HUMAN » Cell adhesion molecule 1 » Immunoglobulin superfamily member 4;IgSF4; Nectin-like protein 2;NECL-2; Spermatogenic immunoglobulin superfamily;SgIgSF; Synaptic cell adhesion molecule;SynCAM; Tumor suppressor in lung cancer 1;TSLC-1;
Hydrophobic Thickness 42.0 ± 2.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -53.9 kcal/mol
ΔGfold -23.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 367-400 (365-402)
Pathways

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

PDB 3bin (B=400-411), 4h5s (B=45-144)
OPM none
Complexes

CRTAM:CADM1_HUMAN

Interactions

CRTAM, Complex: CRTAM:CADM1, PDBID: 4H5S

ITB4, Complex: CADM1:ITB4, PubMed

Domains

AA: 48-142, PDBID: 4H5S, Subunit B, Seq Identity:100%, Immunoglobulin V-set domain

AA: 147-230, PDBID: 4BFG, Subunit A, Seq Identity:33%, CD80-like C2-set immunoglobulin domain

AA: 242-317, PDBID: 2OM5, Subunit A, Seq Identity:34%, Immunoglobulin domain

UniProt annotation for CADM1_HUMAN » Cell adhesion molecule 1
FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

SUBUNIT: Homodimer. Interacts with FARP1 (By similarity). Interacts with CRTAM. Interacts (via C-terminus) with EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6.

DOMAIN: The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.

UniProt features for CADM1_HUMAN » Cell adhesion molecule 1
SIGNAL 1 44 Potential.
CHAIN 45 442 Cell adhesion molecule 1.
DOMAIN 45 139 Ig-like V-type.
DOMAIN 144 238 Ig-like C2-type 1.
DOMAIN 243 329 Ig-like C2-type 2.
DISULFID 64 124 By similarity.
DISULFID 166 220 By similarity.
DISULFID 267 313 By similarity.
Amino Acid Sequence for CADM1_HUMAN » Cell adhesion molecule 1
MASVVLPSGS QCAAAAAAAA PPGLRLRLLL LLFSAAALIP TGDGQNLFTK DVTVIEGEVA TISCQVNKSD DSVIQLLNPN RQTIYFRDFR PLKDSRFQLL NFSSSELKVS LTNVSISDEG RYFCQLYTDP PQESYTTITV LVPPRNLMID IQKDTAVEGE EIEVNCTAMA SKPATTIRWF KGNTELKGKS EVEEWSDMYT VTSQLMLKVH KEDDGVPVIC QVEHPAVTGN LQTQRYLEVQ YKPQVHIQMT YPLQGLTREG DALELTCEAI GKPQPVMVTW VRVDDEMPQH AVLSGPNLFI NNLNKTDNGT YRCEASNIVG KAHSDYMLYV YDPPTTIPPP TTTTTTTTTT TTTILTIITD SRAGEEGSIR AVDHAVIGGV VAVVVFAMLC LLIILGRYFA RHKGTYFTHE AKGADDAADA DTAIINAEGG QNNSEEKKEY FI