CADH9_HUMAN » Cadherin-9

CADH9_HUMAN » Cadherin-9
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADH9_HUMAN » Cadherin-9 »
Hydrophobic Thickness 32.4 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -54.2 kcal/mol
ΔGfold -31.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 611-638 (609-643)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes none
Interactions

CAD10, Complex: CAD10:CADH9, PubMed

CAD15, Complex: CADH9:CAD15, PubMed

CAD18, Complex: CAD18:CADH9, PubMed

CADH6, Complex: CADH9:CADH6, PubMed

CADH7, Complex: CADH9:CADH7, PubMed

Domains

AA: 59-150, PDBID: 3LND, Subunit B, Seq Identity:75%, Cadherin domain

AA: 164-259, PDBID: 3LND, Subunit B, Seq Identity:87%, Cadherin domain

AA: 273-375, PDBID: 2A62, Subunit A, Seq Identity:38%, Cadherin domain

AA: 388-479, PDBID: 3PPE, Subunit A, Seq Identity:30%, Cadherin domain

AA: 492-589, PDBID: 1EDH, Subunit B, Seq Identity:24%, Cadherin domain

AA: 637-784, PDBID: 3L6X, Subunit B, Seq Identity:48%, Cadherin cytoplasmic region

UniProt annotation for CADH9_HUMAN » Cadherin-9
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CADH9_HUMAN » Cadherin-9
SIGNAL 1 21 Potential.
PROPEP 22 53 Potential.
CHAIN 54 789 Cadherin-9.
DOMAIN 54 159 Cadherin 1.
DOMAIN 160 268 Cadherin 2.
DOMAIN 269 383 Cadherin 3.
DOMAIN 384 486 Cadherin 4.
DOMAIN 487 608 Cadherin 5.
Amino Acid Sequence for CADH9_HUMAN » Cadherin-9
MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR TKRGWMWNQF FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL FVIDENTGDI HAAKKLDREE KSLYILRAKA IDRKTGRQVE PESEFIIKIH DINDNEPKFT KDLYTASVPE MSGVGTSVIQ VTATDADDAN YGNSAKVVYS ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD MGGQMGGLSG TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS NTHPDPRFLH LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS IIGQVTAYDP DARNNLIKYS VDRHTDMDRI FGIHSENGSI FTLKALDRES SPWHNITVTA TEINNPKQSS HIPVFIRILD INDHAPEFAM YYETFVCENA KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV DNKDNTAGIM TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD DVRDNIVTYN DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI RRTVPLWENI DVQDFIHRRL KENDADPSAP PYDSLATYAY EGNDSIADSL SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD