CADH8_HUMAN » Cadherin-8

CADH8_HUMAN » Cadherin-8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADH8_HUMAN » Cadherin-8 »
Hydrophobic Thickness 41.2 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -67.3 kcal/mol
ΔGfold -31.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 616-648 (616-648)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes

CADH8:CADH8_MOUSE

Interactions

CADH8, Complex: Homodimer of cadherin-8, PDBID: 1ZXK

Domains

AA: 67-158, PDBID: 1ZXK, Subunit B, Seq Identity:97%, Cadherin domain

AA: 172-267, PDBID: 2A62, Subunit A, Seq Identity:100%, Cadherin domain

AA: 281-383, PDBID: 2A62, Subunit A, Seq Identity:97%, Cadherin domain

AA: 396-487, PDBID: 4ZPL, Subunit A, Seq Identity:28%, Cadherin domain

AA: 500-597, PDBID: 3Q2W, Subunit A, Seq Identity:33%, Cadherin domain

AA: 645-793, PDBID: 1I7W, Subunit B, Seq Identity:42%, Cadherin cytoplasmic region

UniProt annotation for CADH8_HUMAN » Cadherin-8
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

TISSUE SPECIFICITY: Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CADH8_HUMAN » Cadherin-8
SIGNAL 1 29 Potential.
PROPEP 30 61 Potential.
CHAIN 62 799 Cadherin-8.
DOMAIN 62 167 Cadherin 1.
DOMAIN 168 276 Cadherin 2.
DOMAIN 277 391 Cadherin 3.
DOMAIN 392 494 Cadherin 4.
DOMAIN 495 616 Cadherin 5.
Amino Acid Sequence for CADH8_HUMAN » Cadherin-8
MPERLAEMLL DLWTPLIILW ITLPPCIYMA PMNQSQVLMS GSPLELNSLG EEQRILNRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL SGDGAGTIFQ INDVTGDIHA IKRLDREEKA EYTLTAQAVD WETSKPLEPP SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS YTLKVEAANV HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY EAFLCENGKP GQVIQTVSAM DKDDPKNGHY FLYSLLPEMV NNPNFTIKKN EDNSLSILAK HNGFNRQKQE VYLLPIIISD SGNPPLSSTS TLTIRVCGCS NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET