CADH7_HUMAN » Cadherin-7

CADH7_HUMAN » Cadherin-7
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADH7_HUMAN » Cadherin-7 »
Hydrophobic Thickness 38.0 ± 3.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -55.5 kcal/mol
ΔGfold -29.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 605-630 (602-636)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes none
Interactions

CAD12, Complex: CAD12:CADH7, PubMed

CAD15, Complex: CADH7:CAD15, PubMed

CADH6, Complex: CADH6:CADH7, PubMed

CADH9, Complex: CADH9:CADH7, PubMed

Domains

AA: 53-144, PDBID: 3LND, Subunit B, Seq Identity:71%, Cadherin domain

AA: 158-253, PDBID: 3LND, Subunit B, Seq Identity:81%, Cadherin domain

AA: 267-369, PDBID: 2A62, Subunit A, Seq Identity:50%, Cadherin domain

AA: 382-473, PDBID: 2EE0, Subunit A, Seq Identity:30%, Cadherin domain

AA: 486-583, PDBID: 3Q2W, Subunit A, Seq Identity:27%, Cadherin domain

AA: 631-779, PDBID: 3L6X, Subunit B, Seq Identity:47%, Cadherin cytoplasmic region

UniProt annotation for CADH7_HUMAN » Cadherin-7
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CADH7_HUMAN » Cadherin-7
SIGNAL 1 27 Potential.
PROPEP 28 47 Potential.
CHAIN 48 785 Cadherin-7.
DOMAIN 49 153 Cadherin 1.
DOMAIN 154 262 Cadherin 2.
DOMAIN 263 377 Cadherin 3.
DOMAIN 378 482 Cadherin 4.
DOMAIN 482 599 Cadherin 5.
Amino Acid Sequence for CADH7_HUMAN » Cadherin-7
MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTSTLTI RVCDCDADGV AQTCNAEAYV LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI VRYDDEGGGE EDTEAFDMAA LRNLNVIRDT KTRRDVTPEI QFLSRPAFKS IPDNVIFREF IWERLKEADV DPGAPPYDSL QTYAFEGNGS VAESLSSLDS ISSNSDQNYD YLSDWGPRFK RLADMYGTGQ ESLYS