CADH6_HUMAN » Cadherin-6

CADH6_HUMAN » Cadherin-6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADH6_HUMAN » Cadherin-6 » Kidney cadherin;K-cadherin;
Hydrophobic Thickness 32.8 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -53.1 kcal/mol
ΔGfold -27.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 614-636 (613-643)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes

CADH6:CADH6_MOUSE

Interactions

CAD10, Complex: CADH6:CAD10, PubMed

CAD18, Complex: CADH6:CAD18, PubMed

CAD19, Complex: CADH6:CAD19, PubMed

CADH6, Complex: Homodimer of cadherin-6, PDBID: 3LND

CADH7, Complex: CADH6:CADH7, PubMed

CADH9, Complex: CADH9:CADH6, PubMed

Domains

AA: 59-150, PDBID: 3LND, Subunit B, Seq Identity:99%, Cadherin domain

AA: 164-259, PDBID: 3LND, Subunit B, Seq Identity:99%, Cadherin domain

AA: 273-375, PDBID: 2A62, Subunit A, Seq Identity:39%, Cadherin domain

AA: 388-479, PDBID: 3Q2W, Subunit A, Seq Identity:30%, Cadherin domain

AA: 492-589, PDBID: 2O72, Subunit A, Seq Identity:22%, Cadherin domain

AA: 637-784, PDBID: 1I7W, Subunit B, Seq Identity:47%, Cadherin cytoplasmic region

UniProt annotation for CADH6_HUMAN » Cadherin-6
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

TISSUE SPECIFICITY: Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CADH6_HUMAN » Cadherin-6
SIGNAL 1 18 Potential.
PROPEP 19 53 Potential.
CHAIN 54 790 Cadherin-6.
DOMAIN 54 159 Cadherin 1.
DOMAIN 160 268 Cadherin 2.
DOMAIN 269 383 Cadherin 3.
DOMAIN 384 486 Cadherin 4.
DOMAIN 487 608 Cadherin 5.
Amino Acid Sequence for CADH6_HUMAN » Cadherin-6
MRTYRYFLLL FWVGQPYPTL STPLSKRTSG FPAKKRALEL SGNSKNELNR SKRSWMWNQF FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL FIINENTGDI QATKRLDREE KPVYILRAQA INRRTGRPVE PESEFIIKIH DINDNEPIFT KEVYTATVPE MSDVGTFVVQ VTATDADDPT YGNSAKVVYS ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD MGGQMGGLSG TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN AEIEYSITDG EGLDMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS NPYVEPRFLY LGPFKDSATV RIVVEDVDEP PVFSKLAYIL QIREDAQINT TIGSVTAQDP DAARNPVKYS VDRHTDMDRI FNIDSGNGSI FTSKLLDRET LLWHNITVIA TEINNPKQSS RVPLYIKVLD VNDNAPEFAE FYETFVCEKA KADQLIQTLH AVDKDDPYSG HQFSFSLAPE AASGSNFTIQ DNKDNTAGIL TRKNGYNRHE MSTYLLPVVI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE DIRDNIVSYN DEGGGEEDTQ AFDIGTLRNP EAIEDNKLRR DIVPEALFLP RRTPTARDNT DVRDFINQRL KENDTDPTAP PYDSLATYAY EGTGSVADSL SSLESVTTDA DQDYDYLSDW GPRFKKLADM YGGVDSDKDS