CADH4_HUMAN » Cadherin-4

CADH4_HUMAN » Cadherin-4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADH4_HUMAN » Cadherin-4 » Retinal cadherin;R-CAD; R-cadherin;
Hydrophobic Thickness 31.6 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -57.6 kcal/mol
ΔGfold -31.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 732-757 (732-763)
Pathways

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

CADH2, Complex: CADH2:CADH4, PubMed

Domains

AA: 30-120, PDBID: 1OP4, Subunit A, Seq Identity:43%, Cadherin prodomain like

AA: 174-268, PDBID: 1NCG, Subunit A, Seq Identity:69%, Cadherin domain

AA: 282-383, PDBID: 1NCJ, Subunit A, Seq Identity:74%, Cadherin domain

AA: 397-499, PDBID: 3Q2W, Subunit A, Seq Identity:61%, Cadherin domain

AA: 512-606, PDBID: 3Q2W, Subunit A, Seq Identity:73%, Cadherin domain

AA: 760-913, PDBID: 3L6X, Subunit B, Seq Identity:53%, Cadherin cytoplasmic region

UniProt annotation for CADH4_HUMAN » Cadherin-4
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

TISSUE SPECIFICITY: Expressed mainly in brain but also found in other tissues.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CADH4_HUMAN » Cadherin-4
SIGNAL 1 20 Potential.
PROPEP 21 169 Potential.
CHAIN 170 916 Cadherin-4.
DOMAIN 170 277 Cadherin 1.
DOMAIN 278 392 Cadherin 2.
DOMAIN 393 507 Cadherin 3.
DOMAIN 508 613 Cadherin 4.
DOMAIN 614 724 Cadherin 5.
Amino Acid Sequence for CADH4_HUMAN » Cadherin-4
MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE GEKLLQVKFS SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF TVTAWDSQTA EKWDAVVRLL VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD TLLPWPQHQN ANGLRRRKRD WVIPPINVPE NSRGPFPQQL VRIRSDKDND IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH ASYHLRAHAV DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE KVQQYTVIVQ ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE VPENRVETVV ANLTVMDRDQ PHSPNWNAVY RIISGDPSGH FSVRTDPVTN EGMVTVVKAV DYELNRAFML TVMVSNQAPL ASGIQMSFQS TAGVTISIMD INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ AVRYSKLSDP ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE LPFVPAAVRK NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL SNTSIIKVKV CPCDDNGDCT TIGAVAAAGL GTGAIVAILI CILILLTMVL LFVMWMKRRE KERHTKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG DIGDFINEGL RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG PRFKKLADMY GGGEED