CADH3_HUMAN » Cadherin-3

CADH3_HUMAN » Cadherin-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADH3_HUMAN » Cadherin-3 » Placental cadherin;P-cadherin;
Hydrophobic Thickness 33.2 ± 2.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -53.0 kcal/mol
ΔGfold -27.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 651-679 (648-681)
Pathways

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes

CADH3:CADH3_MOUSE

Interactions

CADH1, Complex: CADH1:CADH3, PubMed

CADH3, Complex: Homodimer of cadherin-3, PDBID: 4NQQ

IGF1R, Complex: CADH3:IGF1R, PubMed

Domains

AA: 112-206, PDBID: 4OY9, Subunit A, Seq Identity:100%, Cadherin domain

AA: 220-319, PDBID: 4OY9, Subunit A, Seq Identity:100%, Cadherin domain

AA: 333-432, PDBID: 3Q2V, Subunit A, Seq Identity:47%, Cadherin domain

AA: 445-539, PDBID: 3Q2V, Subunit A, Seq Identity:47%, Cadherin domain

AA: 678-826, PDBID: 3L6X, Subunit B, Seq Identity:76%, Cadherin cytoplasmic region

UniProt annotation for CADH3_HUMAN » Cadherin-3
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

SUBUNIT: Interacts with CDCP1 and CTNNB1.

TISSUE SPECIFICITY: Expressed in some normal epithelial tissues and in some carcinoma cell lines.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

DISEASE: Hypotrichosis congenital with juvenile macular dystrophy (HJMD) OMIM: A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life. mutations affecting the gene represented in this entry.

DISEASE: Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS) OMIM: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly. mutations affecting the gene represented in this entry.

UniProt features for CADH3_HUMAN » Cadherin-3
SIGNAL 1 24 Potential.
PROPEP 25 107
CHAIN 108 829 Cadherin-3.
DOMAIN 108 215 Cadherin 1.
DOMAIN 216 328 Cadherin 2.
DOMAIN 329 440 Cadherin 3.
DOMAIN 441 546 Cadherin 4.
DOMAIN 547 650 Cadherin 5.
Amino Acid Sequence for CADH3_HUMAN » Cadherin-3
MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA LGKVFMGCPG QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR ILRRHKRDWV VAPISVPENG KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA DSPPEGVFAV EKETGWLLLN KPLDREEIAK YELFGHAVSE NGASVEDPMN ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT DEDDAIYTYN GVVAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA TDMDGDGSTT TAVAVVEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT VTDLDAPNSP AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA KNQHTLYVEV TNEAPFVLKL PTSTATIVVH VEDVNEAPVF VPPSKVVEVQ EGIPTGEPVC VYTAEDPDKE NQKISYRILR DPAGWLAMDP DSGQVTAVGT LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID VNDHGPVPEP RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD TVVLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP WKGGFILPVL GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY YGEEGGGEED QDYDITQLHR GLEARPEVVL RNDVAPTIIP TPMYRPRPAN PDEIGNFIIE NLKAANTDPT APPYDTLLVF DYEGSGSDAA SLSSLTSSAS DQDQDYDYLN EWGSRFKKLA DMYGGGEDD