CADH2_HUMAN » Cadherin-2

CADH2_HUMAN » Cadherin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADH2_HUMAN » Cadherin-2 » CDw325;Neural cadherin;N-cadherin;
Hydrophobic Thickness 32.4 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -59.4 kcal/mol
ΔGfold -33.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 722-747 (722-755)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes

CADH2:CADH2_MOUSE

Interactions

BOC, Complex: BOC:CADH2, PubMed

CAD11, Complex: CADH2:CAD11, PubMed

CADH2, Complex: Homodimer of cadherin-2, PDBID: 4NUP

CADH4, Complex: CADH2:CADH4, PubMed

CDON, Complex: CDON:CADH2, PubMed

DDR1, Complex: CADH2:DDR1

DDR2, Complex: CADH2:DDR2

FGFR4, Complex: CADH2:FGFR4, PubMed

KTN1, Complex: KTN1:CADH2, PubMed

PTPRB, Complex: PTPRB:CADH2, PubMed

PTPRC, Complex: CADH2:PTPRC, PubMed

PTPRG, Complex: CADH2:PTPRG, PubMed

PTPRJ, Complex: PTPRJ:CADH2, PubMed

PTPRK, Complex: CADH2:PTPRK

PTPRO, Complex: CADH2:PTPRO

PTPRQ, Complex: PTPRQ:CADH2, PubMed

PTPRR, Complex: CADH2:PTPRR

PTPRU, Complex: PTPRU:CADH2, PubMed

RYK, Complex: RYK:CADH2, PubMed

SSRD, Complex: CADH2:SSRD, PubMed

Domains

AA: 31-121, PDBID: 1OP4, Subunit A, Seq Identity:92%, Cadherin prodomain like

AA: 164-258, PDBID: 1NCG, Subunit A, Seq Identity:99%, Cadherin domain

AA: 272-373, PDBID: 1NCJ, Subunit A, Seq Identity:95%, Cadherin domain

AA: 387-489, PDBID: 3Q2W, Subunit A, Seq Identity:97%, Cadherin domain

AA: 502-596, PDBID: 3Q2W, Subunit A, Seq Identity:99%, Cadherin domain

AA: 608-701, PDBID: 3Q2W, Subunit A, Seq Identity:98%, Cadherin domain

AA: 751-904, PDBID: 3L6X, Subunit B, Seq Identity:53%, Cadherin cytoplasmic region

UniProt annotation for CADH2_HUMAN » Cadherin-2
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

SUBUNIT: Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity).

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).

UniProt features for CADH2_HUMAN » Cadherin-2
SIGNAL 1 25 Potential.
PROPEP 26 159
CHAIN 160 906 Cadherin-2.
DOMAIN 160 267 Cadherin 1.
DOMAIN 268 382 Cadherin 2.
DOMAIN 383 497 Cadherin 3.
DOMAIN 498 603 Cadherin 4.
DOMAIN 604 714 Cadherin 5.
Amino Acid Sequence for CADH2_HUMAN » Cadherin-2
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM YGGGDD