CAD26_HUMAN » Cadherin-like protein 26

CAD26_HUMAN » Cadherin-like protein 26
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD26_HUMAN » Cadherin-like protein 26 » Cadherin-like protein VR20;
Hydrophobic Thickness 40.8 ± 5.8 Å
Tilt Angle 14 ± 7°
ΔGtransfer -30.3 kcal/mol
ΔGfold -21.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 613-642 (608-643)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 170-266, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 280-388, PDBID: 3Q2V, Subunit A, Seq Identity:35%, Cadherin domain

AA: 401-490, PDBID: 3Q2W, Subunit A, Seq Identity:43%, Cadherin domain

UniProt annotation for CAD26_HUMAN » Cadherin-like protein 26
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD26_HUMAN » Cadherin-like protein 26
SIGNAL 1 26 Potential.
CHAIN 27 852 Cadherin-like protein 26.
DOMAIN 35 165 Cadherin 1.
DOMAIN 166 275 Cadherin 2.
DOMAIN 276 396 Cadherin 3.
DOMAIN 397 500 Cadherin 4.
Amino Acid Sequence for CAD26_HUMAN » Cadherin-like protein 26
MAMRSGRHPS LLLLLVLLLW LLQVSIIDSV QQETDDLTKQ TKEKIYQPLR RSKRRWVITT LELEEEDPGP FPKLIGELFN NMSYNMSLMY LISGPGVDEY PEIGLFSLED HENGRIYVHR PVDREMTPSF TVYFDVVERS TGKIVDTSLI FNIRISDVND HAPQFPEKEF NITVQENQSA GQPIFQMLAV DLDEENTPNS QVLYFLISQT PLLKESGFRV DRLSGEIRLS GCLDYETAPQ FTLLIRARDC GEPSLSSTTT VHVDVQEGNN HRPAFTQENY KVQIPEGRAS QGVLRLLVQD RDSPFTSAWR AKFNILHGNE EGHFDISTDP ETNEGILNVI KPLDYETRPA QSLIIVVENE ERLVFCERGK LQPPRKAAAS ATVSVQVTDA NDPPAFHPQS FIVNKEEGAR PGTLLGTFNA MDPDSQIRYE LVHDPANWVS VDKNSGVVIT VEPIDRESPH VNNSFYVIII HAVDDGFPPQ TATGTLMLFL SDINDNVPTL RPRSRYMEVC ESAVHEPLHI EAEDPDLEPF SDPFTFELDN TWGNAEDTWK LGRNWGQSVE LLTLRSLPRG NYLVPLFIGD KQGLSQKQTV HVRICPCASG LTCVELADAE VGLHVGALFP VCAAFVALAV ALLFLLRCYF VLEPKRHGCS VSNDEGHQTL VMYNAESKGT SAQTWSDVEG QRPALLICTA AAGPTQGVKA YPDATMHRQL LAPVEGRMAE TLNQSKERNR FSLSRGCIIP QGRATAGRGL PQDIYKEMMP RRLTQTGKRK HGALARTPSF KKVVYDHKED EENKAGRKQR SHLFKVMQLR NEQGGVRVQS AHSPSPLNKK ACFPGDYRGE SAGGHNCRAV SG