CAD24_HUMAN » Cadherin-24

CAD24_HUMAN » Cadherin-24
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD24_HUMAN » Cadherin-24 »
Hydrophobic Thickness 39.2 ± 1.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -52.5 kcal/mol
ΔGfold -24.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 637-662 (634-666)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 50-141, PDBID: 2A4C, Subunit B, Seq Identity:72%, Cadherin domain

AA: 155-250, PDBID: 2A4E, Subunit A, Seq Identity:78%, Cadherin domain

AA: 264-366, PDBID: 2A62, Subunit A, Seq Identity:36%, Cadherin domain

AA: 379-462, PDBID: 2WBX, Subunit A, Seq Identity:31%, Cadherin domain

AA: 663-814, PDBID: 1I7W, Subunit B, Seq Identity:36%, Cadherin cytoplasmic region

UniProt annotation for CAD24_HUMAN » Cadherin-24
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

SUBUNIT: Associates with alpha-, beta- and delta-catenins.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD24_HUMAN » Cadherin-24
SIGNAL 1 19 Potential.
PROPEP 21 44 Potential.
CHAIN 45 819 Cadherin-24.
DOMAIN 46 150 Cadherin 1.
DOMAIN 151 259 Cadherin 2.
DOMAIN 260 374 Cadherin 3.
DOMAIN 375 517 Cadherin 4.
DOMAIN 517 630 Cadherin 5.
Amino Acid Sequence for CAD24_HUMAN » Cadherin-24
MWGLVRLLLA WLGGWGCMGR LAAPARAWAG SREHPGPALL RTRRSWVWNQ FFVIEEYAGP EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN IHVTKSLDRE EKAQYVLLAQ AVDRASNRPL EPPSEFIIKV QDINDNPPIF PLGPYHATVP EMSNVGTSVI QVTAHDADDP SYGNSAKLVY TVLDGLPFFS VDPQTGVVRT AIPNMDRETQ EEFLVVIQAK DMGGHMGGLS GSTTVTVTLS DVNDNPPKFP QSLYQFSVVE TAGPGTLVGR LRAQDPDLGD NALMAYSILD GEGSEAFSIS TDLQGRDGLL TVRKPLDFES QRSYSFRVEA TNTLIDPAYL RRGPFKDVAS VRVAVQDAPE PPAFTQAAYH LTVPENKAPG TLVGQISAAD LDSPASPIRY SILPHSDPER CFSIQPEEGT IHTAAPLDRE ARAWHNLTVL ATELGWSWGP ERGWVPLLVA EWSAPAAPPQ RSPVGSAVGI PQDSSAQASR VQVAIQTLDE NDNAPQLAEP YDTFVCDSAA PGQLIQVIRA LDRDEVGNSS HVSFQGPLGP DANFTVQDNR DGSASLLLPS RPAPPRHAPY LVPIELWDWG QPALSSTATV TVSVCRCQPD GSVASCWPEA HLSAAGLSTG ALLAIITCVG ALLALVVLFV ALRRQKQEAL MVLEEEDVRE NIITYDDEGG GEEDTEAFDI TALQNPDGAA PPAPGPPARR DVLPRARVSR QPRPPGPADV AQLLALRLRE ADEDPGVPPY DSVQVYGYEG RGSSCGSLSS LGSGSEAGGA PGPAEPLDDW GPLFRTLAEL YGAKEPPAP