CAD22_HUMAN » Cadherin-22

CAD22_HUMAN » Cadherin-22
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD22_HUMAN » Cadherin-22 » Pituitary and brain cadherin;PB-cadherin;
Hydrophobic Thickness 30.4 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -52.5 kcal/mol
ΔGfold -27.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 624-648 (624-650)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 67-159, PDBID: 1ZVN, Subunit A, Seq Identity:69%, Cadherin domain

AA: 173-268, PDBID: 2A4E, Subunit A, Seq Identity:60%, Cadherin domain

AA: 282-386, PDBID: 2A62, Subunit A, Seq Identity:28%, Cadherin domain

AA: 400-490, PDBID: 4NQQ, Subunit D, Seq Identity:31%, Cadherin domain

AA: 503-600, PDBID: 2O72, Subunit A, Seq Identity:23%, Cadherin domain

AA: 648-819, PDBID: 1I7W, Subunit B, Seq Identity:31%, Cadherin cytoplasmic region

UniProt annotation for CAD22_HUMAN » Cadherin-22
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD22_HUMAN » Cadherin-22
SIGNAL 1 34 Potential.
CHAIN 35 828 Cadherin-22.
DOMAIN 64 168 Cadherin 1.
DOMAIN 169 277 Cadherin 2.
DOMAIN 278 394 Cadherin 3.
DOMAIN 395 498 Cadherin 4.
DOMAIN 499 616 Cadherin 5.
Amino Acid Sequence for CAD22_HUMAN » Cadherin-22
MRPRPEGRGL RAGVALSPAL LLLLLLPPPP TLLGRLWAAG TPSPSAPGAR QDGALGAGRV KRGWVWNQFF VVEEYTGTEP LYVGKIHSDS DEGDGAIKYT ISGEGAGTIF LIDELTGDIH AMERLDREQK TFYTLRAQAR DRATNRLLEP ESEFIIKVQD INDSEPRFLH GPYIGSVAEL SPTGTSVMQV MASDADDPTY GSSARLVYSV LDGEHHFTVD PKTGVIRTAV PDLDRESQER YEVVIQATDM AGQLGGLSGS TTVTIVVTDV NDNPPRFPQK MYQFSIQESA PIGTAVGRVK AEDSDVGENT DMTYHLKDES SSGGDVFKVT TDSDTQEAII VVQKRLDFES QPVHTVILEA LNKFVDPRFA DLGTFRDQAI VRVAVTDVDE PPEFRPPSGL LEVQEDAQVG SLVGVVTARD PDAANRPVRY AIDRESDLDQ IFDIDADTGA IVTGKGLDRE TAGWHNITVL AMEADNHAQL SRASLRIRIL DVNDNPPELA TPYEAAVCED AKPGQLIQTI SVVDRDEPQG GHRFYFRLVP EAPSNPHFSL LDIQDNTAAV HTQHVGFNRQ EQDVFFLPIL VVDSGPPTLS STGTLTIRIC GCDSSGTIQS CNTTAFVMAA SLSPGALIAL LVCVLILVVL VLLILTLRRH HKSHLSSDED EDMRDNVIKY NDEGGGEQDT EAYDMSALRS LYDFGELKGG DGGGSAGGGA GGGSGGGAGS PPQAHLPSER HSLPQGPPSP EPDFSVFRDF ISRKVALADG DLSVPPYDAF QTYAFEGADS PAASLSSLHS GSSGSEQDFA YLSSWGPRFR PLAALYAGHR GDDEAQAS