CAD20_HUMAN » Cadherin-20

CAD20_HUMAN » Cadherin-20
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD20_HUMAN » Cadherin-20 »
Hydrophobic Thickness 31.2 ± 2.2 Å
Tilt Angle 3 ± 2°
ΔGtransfer -47.7 kcal/mol
ΔGfold -27.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 620-642 (619-646)
Pathways none
PDB none
OPM none
Complexes

CAD20:CAD20_CHICK

Interactions

CAD20, Complex: Homodimer of cadherin-20, PDBID: 1ZVN

Domains

AA: 64-156, PDBID: 1ZVN, Subunit A, Seq Identity:98%, Cadherin domain

AA: 170-265, PDBID: 3LND, Subunit B, Seq Identity:81%, Cadherin domain

AA: 279-381, PDBID: 2A62, Subunit A, Seq Identity:49%, Cadherin domain

AA: 394-485, PDBID: 4ZI9, Subunit B, Seq Identity:32%, Cadherin domain

AA: 498-595, PDBID: 2O72, Subunit A, Seq Identity:26%, Cadherin domain

AA: 643-794, PDBID: 3L6X, Subunit B, Seq Identity:35%, Cadherin cytoplasmic region

UniProt annotation for CAD20_HUMAN » Cadherin-20
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

TISSUE SPECIFICITY: Expressed in placenta, adult brain, and fetal brain.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD20_HUMAN » Cadherin-20
SIGNAL 1 34 Potential.
PROPEP 35 59 Potential.
CHAIN 60 801 Cadherin-20.
DOMAIN 61 165 Cadherin 1.
DOMAIN 166 274 Cadherin 2.
DOMAIN 275 389 Cadherin 3.
DOMAIN 390 494 Cadherin 4.
DOMAIN 494 610 Cadherin 5.
Amino Acid Sequence for CAD20_HUMAN » Cadherin-20
MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK PQSHQRTKRS WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG EGAGIVFTID DTTGDIHAIQ RLDREERAQY TLRAQALDRR TGRPMEPESE FIIKIQDIND NEPKFLDGPY VATVPEMSPV GTSVIQVTAT DADDPTYGNS ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV IIQAKDMGGQ LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT LKVEGANPHL EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE DVAIGTTIQI ISAKDPDVTN NSIRYSIDRS SDPGRFFYVD ITTGALMTAR PLDREEFSWH NITVLAMEMN NPSQVGSVPV TIKVLDVNDN APEFPRFYEA FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN PNFTIRDNQD NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY IIDDEENIHE NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD MLPEIESLSR YVPQTCAVNS TVHSYVLAKL YEADMDLWAP PFDSLQTYMF EGDGSVAGSL SSLQSATSDS EQSFDFLTDW GPRFRKLAEL YGASEGPAPL W