CAD17_HUMAN » Cadherin-17

CAD17_HUMAN » Cadherin-17
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD17_HUMAN » Cadherin-17 » Intestinal peptide-associated transporter HPT-1;Liver-intestine cadherin;LI-cadherin;
Hydrophobic Thickness 34.4 ± 1.2 Å
Tilt Angle 2 ± 2°
ΔGtransfer -61.1 kcal/mol
ΔGfold -26.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 786-808 (783-814)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 131-235, PDBID: 1NCJ, Subunit A, Seq Identity:35%, Cadherin domain

AA: 243-331, PDBID: 1ZXK, Subunit B, Seq Identity:33%, Cadherin domain

AA: 345-440, PDBID: 2WBX, Subunit A, Seq Identity:29%, Cadherin domain

AA: 456-558, PDBID: 2WBX, Subunit A, Seq Identity:29%, Cadherin domain

AA: 571-657, PDBID: 3Q2V, Subunit A, Seq Identity:33%, Cadherin domain

UniProt annotation for CAD17_HUMAN » Cadherin-17
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

TISSUE SPECIFICITY: Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD17_HUMAN » Cadherin-17
SIGNAL 1 22 Potential.
CHAIN 23 832 Cadherin-17.
DOMAIN 30 128 Cadherin 1.
DOMAIN 129 244 Cadherin 2.
DOMAIN 245 340 Cadherin 3.
DOMAIN 341 449 Cadherin 4.
DOMAIN 450 566 Cadherin 5.
DOMAIN 567 667 Cadherin 6.
DOMAIN 668 777 Cadherin 7.
Amino Acid Sequence for CAD17_HUMAN » Cadherin-17
MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA TDLDDPATPN GQLYYQIVIQ LPMINNVMYF QINNKTGAIS LTREGSQELN PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK APKPVEMVEN STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ ENERLGNSIG TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA GMLQLAKQSL KKQDTPQYNL TIEVSDKDFK TLCFVQINVI DINDQIPIFE KSDYGNLTLA EDTNIGSTIL TIQATDADEP FTGSSKILYH IIKGDSEGRL GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV FGVKYNASSF AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV SEFHLILMDV NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG PHFTFSLGSG SLQNDWEVSK INGTHARLST RHTDFEEREY VVLIRINDGG RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT GIPTVGMAVG ILLTTLLVIG IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS