CAD16_HUMAN » Cadherin-16

CAD16_HUMAN » Cadherin-16
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD16_HUMAN » Cadherin-16 » Kidney-specific cadherin;Ksp-cadherin;
Hydrophobic Thickness 38.4 ± 0.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -61.4 kcal/mol
ΔGfold -25.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 780-808 (780-814)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 131-234, PDBID: 1NCJ, Subunit A, Seq Identity:31%, Cadherin domain

AA: 258-327, PDBID: 3LND, Subunit B, Seq Identity:27%, Cadherin domain

AA: 341-440, PDBID: 3PPE, Subunit A, Seq Identity:31%, Cadherin domain

AA: 456-556, PDBID: 2A62, Subunit A, Seq Identity:27%, Cadherin domain

UniProt annotation for CAD16_HUMAN » Cadherin-16
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

TISSUE SPECIFICITY: Kidney specific.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD16_HUMAN » Cadherin-16
SIGNAL 1 18 Potential.
CHAIN 19 829 Cadherin-16.
DOMAIN 25 126 Cadherin 1.
DOMAIN 131 235 Cadherin 2.
DOMAIN 242 336 Cadherin 3.
DOMAIN 341 449 Cadherin 4.
DOMAIN 455 564 Cadherin 5.
DOMAIN 569 665 Cadherin 6.
REGION 666 786 Ectodomain G.
Amino Acid Sequence for CAD16_HUMAN » Cadherin-16
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV