CAD15_HUMAN » Cadherin-15

CAD15_HUMAN » Cadherin-15
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD15_HUMAN » Cadherin-15 » Cadherin-14;Muscle cadherin;M-cadherin;
Hydrophobic Thickness 37.6 ± 4.0 Å
Tilt Angle 18 ± 16°
ΔGtransfer -31.6 kcal/mol
ΔGfold -27.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 602-629 (602-634)
Pathways

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

BOC, Complex: CAD15:BOC, PubMed

CADH7, Complex: CADH7:CAD15, PubMed

CADH9, Complex: CADH9:CAD15, PubMed

CDON, Complex: CAD15:CDON, PubMed

Domains

AA: 50-143, PDBID: 1NCG, Subunit A, Seq Identity:45%, Cadherin domain

AA: 157-251, PDBID: 2O72, Subunit A, Seq Identity:48%, Cadherin domain

AA: 266-367, PDBID: 3Q2W, Subunit A, Seq Identity:33%, Cadherin domain

AA: 380-474, PDBID: 3Q2W, Subunit A, Seq Identity:40%, Cadherin domain

AA: 632-783, PDBID: 1I7W, Subunit B, Seq Identity:50%, Cadherin cytoplasmic region

UniProt annotation for CAD15_HUMAN » Cadherin-15
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

TISSUE SPECIFICITY: Expressed in the brain and cerebellum.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

DISEASE: Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).

DISEASE: Mental retardation, autosomal dominant 3 (MRD3) OMIM: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. disease is caused by mutations affecting the gene represented in this entry.

UniProt features for CAD15_HUMAN » Cadherin-15
SIGNAL 1 21 Potential.
PROPEP 22 60 Potential.
CHAIN 61 814 Cadherin-15.
DOMAIN 61 152 Cadherin 1.
DOMAIN 153 260 Cadherin 2.
DOMAIN 261 375 Cadherin 3.
DOMAIN 376 481 Cadherin 4.
DOMAIN 482 590 Cadherin 5.
Amino Acid Sequence for CAD15_HUMAN » Cadherin-15
MDAAFLLVLG LLAQSLCLSL GVPGWRRPTT LYPWRRAPAL SRVRRAWVIP PISVSENHKR LPYPLVQIKS DKQQLGSVIY SIQGPGVDEE PRGVFSIDKF TGKVFLNAML DREKTDRFRL RAFALDLGGS TLEDPTDLEI VVVDQNDNRP AFLQEAFTGR VLEGAVPGTY VTRAEATDAD DPETDNAALR FSILQQGSPE LFSIDELTGE IRTVQVGLDR EVVAVYNLTL QVADMSGDGL TATASAIITL DDINDNAPEF TRDEFFMEAI EAVSGVDVGR LEVEDRDLPG SPNWVARFTI LEGDPDGQFT IRTDPKTNEG VLSIVKALDY ESCEHYELKV SVQNEAPLQA AALRAERGQA KVRVHVQDTN EPPVFQENPL RTSLAEGAPP GTLVATFSAR DPDTEQLQRL SYSKDYDPED WLQVDAATGR IQTQHVLSPA SPFLKGGWYR AIVLAQDDAS QPRTATGTLS IEILEVNDHA PVLAPPPPGS LCSEPHQGPG LLLGATDEDL PPHGAPFHFQ LSPRLPELGR NWSLSQVNVS HARLRPRHQV PEGLHRLSLL LRDSGQPPQQ REQPLNVTVC RCGKDGVCLP GAAALLAGGT GLSLGALVIV LASALLLLVL VLLVALRARF WKQSRGKGLL HGPQDDLRDN VLNYDEQGGG EEDQDAYDIS QLRHPTALSL PLGPPPLRRD APQGRLHPQP PRVLPTSPLD IADFINDGLE AADSDPSVPP YDTALIYDYE GDGSVAGTLS SILSSQGDED QDYDYLRDWG PRFARLADMY GHPCGLEYGA RWDHQAREGL SPGALLPRHR GRTA