CAD12_HUMAN » Cadherin-12

CAD12_HUMAN » Cadherin-12
Magnify CAD12_HUMAN » Cadherin-12Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD12_HUMAN » Cadherin-12 » Brain cadherin;BR-cadherin; Neural type cadherin 2;N-cadherin 2;
Hydrophobic Thickness 29.2 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -53.8 kcal/mol
ΔGfold -28.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 615-637 (614-641)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes none
Interactions

CAD18, Complex: CAD18:CAD12, PubMed

CADH7, Complex: CAD12:CADH7, PubMed

Domains

AA: 59-151, PDBID: 1ZVN, Subunit A, Seq Identity:70%, Cadherin domain

AA: 165-260, PDBID: 3LND, Subunit B, Seq Identity:79%, Cadherin domain

AA: 274-376, PDBID: 2A62, Subunit A, Seq Identity:60%, Cadherin domain

AA: 389-480, PDBID: 3LND, Subunit B, Seq Identity:31%, Cadherin domain

AA: 493-590, PDBID: 1EDH, Subunit B, Seq Identity:26%, Cadherin domain

AA: 638-785, PDBID: 1I7W, Subunit B, Seq Identity:46%, Cadherin cytoplasmic region

UniProt annotation for CAD12_HUMAN » Cadherin-12
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

TISSUE SPECIFICITY: Brain.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD12_HUMAN » Cadherin-12
SIGNAL 1 23 Potential.
PROPEP 24 54 Potential.
CHAIN 55 794 Cadherin-12.
DOMAIN 55 160 Cadherin 1.
DOMAIN 161 269 Cadherin 2.
DOMAIN 270 384 Cadherin 3.
DOMAIN 385 487 Cadherin 4.
DOMAIN 488 609 Cadherin 5.
Amino Acid Sequence for CAD12_HUMAN » Cadherin-12
MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ RVKRGWVWNQ FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPKF LDGPYVATVP EMSPVGAYVL QVKATDADDP TYGNSARVVY SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDGNEGT IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL PRQRPPMEDN TDIRDFIHQR LQENDVDPTA PPYDSLATYA YEGSGSVAES LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD MFGEEESYNP DKVT