CAD11_HUMAN » Cadherin-11

CAD11_HUMAN » Cadherin-11
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD11_HUMAN » Cadherin-11 » OSF-4;Osteoblast cadherin;OB-cadherin;
Hydrophobic Thickness 34.8 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -61.2 kcal/mol
ΔGfold -30.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 614-640 (613-644)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes

CAD11:CAD11_MOUSE

Interactions

CAD11, Complex: Homodimer of cadherin-11, PDBID: 2A4C

CADH2, Complex: CADH2:CAD11, PubMed

Domains

AA: 59-150, PDBID: 2A4C, Subunit B, Seq Identity:100%, Cadherin domain

AA: 164-259, PDBID: 2A4E, Subunit A, Seq Identity:100%, Cadherin domain

AA: 273-375, PDBID: 2A62, Subunit A, Seq Identity:62%, Cadherin domain

AA: 388-479, PDBID: 2EE0, Subunit A, Seq Identity:34%, Cadherin domain

AA: 641-789, PDBID: 3L6X, Subunit B, Seq Identity:44%, Cadherin cytoplasmic region

UniProt annotation for CAD11_HUMAN » Cadherin-11
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

SUBUNIT: Interacts with PCDH8.

TISSUE SPECIFICITY: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

DISEASE: Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

UniProt features for CAD11_HUMAN » Cadherin-11
SIGNAL 1 22 Potential.
PROPEP 23 53 Potential.
CHAIN 54 796 Cadherin-11.
DOMAIN 54 159 Cadherin 1.
DOMAIN 160 268 Cadherin 2.
DOMAIN 269 383 Cadherin 3.
DOMAIN 384 486 Cadherin 4.
DOMAIN 487 612 Cadherin 5.
Amino Acid Sequence for CAD11_HUMAN » Cadherin-11
MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS