CAD10_HUMAN » Cadherin-10

CAD10_HUMAN » Cadherin-10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CAD10_HUMAN » Cadherin-10 » T2-cadherin;
Hydrophobic Thickness 32.0 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -54.5 kcal/mol
ΔGfold -31.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 612-635 (611-641)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes none
Interactions

CADH6, Complex: CADH6:CAD10, PubMed

CADH9, Complex: CAD10:CADH9, PubMed

Domains

AA: 60-151, PDBID: 3LND, Subunit B, Seq Identity:87%, Cadherin domain

AA: 165-260, PDBID: 3LND, Subunit B, Seq Identity:89%, Cadherin domain

AA: 274-376, PDBID: 2A62, Subunit A, Seq Identity:36%, Cadherin domain

AA: 389-480, PDBID: 2WCP, Subunit A, Seq Identity:29%, Cadherin domain

AA: 493-587, PDBID: 2O72, Subunit A, Seq Identity:26%, Cadherin domain

AA: 635-782, PDBID: 1I7W, Subunit B, Seq Identity:46%, Cadherin cytoplasmic region

UniProt annotation for CAD10_HUMAN » Cadherin-10
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

TISSUE SPECIFICITY: Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for CAD10_HUMAN » Cadherin-10
SIGNAL 1 22 Potential.
PROPEP 23 54 Potential.
CHAIN 55 788 Cadherin-10.
DOMAIN 55 160 Cadherin 1.
DOMAIN 161 269 Cadherin 2.
DOMAIN 270 384 Cadherin 3.
DOMAIN 385 487 Cadherin 4.
DOMAIN 488 606 Cadherin 5.
Amino Acid Sequence for CAD10_HUMAN » Cadherin-10
MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRF SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE LSQWHNLTVI AAEINNPKET TRVAVFVRIL DVNDNAPQFA VFYDTFVCEN ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN EDNTARILTR KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI RDNIVSYNDE GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR TPTAPDNTDV RDFINERLKE HDLDPTAPPY DSLATYAYEG NDSIAESLSS LESGTTEGDQ NYDYLREWGP RFNKLAEMYG GGESDKDS