CABP8_HUMAN » Calcium-binding protein 8

CABP8_HUMAN » Calcium-binding protein 8
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
CABP8_HUMAN » Calcium-binding protein 8 » CaBP8; Calneuron I;Calneuron-1;
Hydrophobic Thickness 30.8 ± 1.0 Å
Tilt Angle 29 ± 1°
ΔGtransfer -22.7 kcal/mol
ΔGfold -18.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 189-214 (185-218)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 38-102, PDBID: 2LV7, Subunit A, Seq Identity:85%, EF-hand domain pair

UniProt annotation for CABP8_HUMAN » Calcium-binding protein 8
FUNCTION: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning.

SUBUNIT: Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).

TISSUE SPECIFICITY: Brain specific.

DOMAIN: The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

UniProt features for CABP8_HUMAN » Calcium-binding protein 8
CHAIN 1 219 Calcium-binding protein 8.
DOMAIN 36 71 EF-hand 1.
DOMAIN 72 107 EF-hand 2.
Amino Acid Sequence for CABP8_HUMAN » Calcium-binding protein 8
MPFHHVTAGL LYKGNYLNRS LSAGSDSEQL ANISVEELDE IREAFRVLDR DGNGFISKQE LGMAMRSLGY MPSEVELAII MQRLDMDGDG QVDFDEFMTI LGPKLVSSEG RDGFLGNTID SIFWQFDMQR ITLEELKHIL YHAFRDHLTM KDIENIIINE EESLNETSGN CQTEFEGVHS QKQNRQTCVR KSLICAFAMA FIISVMLIAA NQILRSGME