CABP7_HUMAN » Calcium-binding protein 7

CABP7_HUMAN » Calcium-binding protein 7
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
CABP7_HUMAN » Calcium-binding protein 7 » CaBP7; Calneuron II;Calneuron-2;
Hydrophobic Thickness 30.8 ± 3.8 Å
Tilt Angle 16 ± 12°
ΔGtransfer -22.4 kcal/mol
ΔGfold -18.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 188-210 (182-214)
Pathways none
PDB 2lv7 (1-100)
OPM none
Complexes none
Interactions none
Domains

AA: 35-99, PDBID: 2LV7, Subunit A, Seq Identity:100%, EF-hand domain pair

UniProt annotation for CABP7_HUMAN » Calcium-binding protein 7
FUNCTION: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.

SUBUNIT: Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).

DOMAIN: The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

UniProt features for CABP7_HUMAN » Calcium-binding protein 7
CHAIN 1 215 Calcium-binding protein 7.
DOMAIN 33 68 EF-hand 1.
DOMAIN 69 104 EF-hand 2.
Amino Acid Sequence for CABP7_HUMAN » Calcium-binding protein 7
MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN GFISKQELGT AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP KLSTSGIPEK FHGTDFDTVF WKCDMQKLTV DELKRLLYDT FCEHLSMKDI ENIIMTEEES HLGTAEECPV DVETCSNQQI RQTCVRKSLI CAFAIAFIIS VMLIAANQVL RSGMK