C99L2_HUMAN » CD99 antigen-like protein 2

C99L2_HUMAN » CD99 antigen-like protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
C99L2_HUMAN » CD99 antigen-like protein 2 » MIC2-like protein 1;
Hydrophobic Thickness 28.0 ± 2.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -28.5 kcal/mol
ΔGfold -12.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 186-206 (186-211)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-94, CD99 antigen like protein 2

AA: 89-239, CD99 antigen like protein 2

UniProt annotation for C99L2_HUMAN » CD99 antigen-like protein 2
FUNCTION: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

TISSUE SPECIFICITY: Expressed in many tissues, with low expression in thymus.

UniProt features for C99L2_HUMAN » CD99 antigen-like protein 2
SIGNAL 1 25 Potential.
CHAIN 26 262 CD99 antigen-like protein 2.
Amino Acid Sequence for C99L2_HUMAN » CD99 antigen-like protein 2
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT TTTTNRPGTT RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRERWNHVTT TTKRPVTTRA PANTLGNDFD LADALDDRND RDDGRRKPIA GGGGFSDKDL EDIVGGGEYK PDKGKGDGRY GSNDDPGSGM VAEPGTIAGV ASALAMALIG AVSSYISYQQ KKFCFSIQQG LNADYVKGEN LEAVVCEEPQ VKYSTLHTQS AEPPPPPEPA RI