C1QR1_HUMAN » Complement component C1q receptor

C1QR1_HUMAN » Complement component C1q receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
C1QR1_HUMAN » Complement component C1q receptor » C1q/MBL/SPA receptor;C1qR; C1qR(p); C1qRp; CDw93;Complement component 1 q subcomponent receptor 1;Matrix-remodeling-associated protein 4;
Hydrophobic Thickness 35.6 ± 4.4 Å
Tilt Angle 40 ± 2°
ΔGtransfer -32.2 kcal/mol
ΔGfold -31.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 577-606 (577-611)
Pathways none
PDB none
OPM none
Complexes none
Interactions

KI2L2, Complex: C1QR1:KI2L2, PubMed

Domains

AA: 42-181, PDBID: 1B08, Subunit A, Seq Identity:21%, Lectin C-type domain

AA: 325-348, PDBID: 1HJ7, Subunit A, Seq Identity:50%, Complement Clr-like EGF-like

AA: 406-430, PDBID: 3V65, Subunit D, Seq Identity:51%, Complement Clr-like EGF-like

UniProt annotation for C1QR1_HUMAN » Complement component C1q receptor
FUNCTION: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

SUBUNIT: Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor.

TISSUE SPECIFICITY: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

UniProt features for C1QR1_HUMAN » Complement component C1q receptor
SIGNAL 1 21
CHAIN 22 652 Complement component C1q receptor.
DOMAIN 32 174 C-type lectin.
DOMAIN 260 301 EGF-like 1.
DOMAIN 302 344 EGF-like 2.
DOMAIN 345 384 EGF-like 3; calcium-binding (Potential).
DOMAIN 385 426 EGF-like 4; calcium-binding (Potential).
DOMAIN 427 468 EGF-like 5; calcium-binding (Potential).
DISULFID 141 165 By similarity.
DISULFID 264 275 By similarity.
DISULFID 271 285 By similarity.
DISULFID 287 300 By similarity.
DISULFID 306 317 By similarity.
DISULFID 311 328 By similarity.
DISULFID 330 343 By similarity.
DISULFID 349 358 By similarity.
DISULFID 354 367 By similarity.
DISULFID 369 383 By similarity.
DISULFID 389 400 By similarity.
DISULFID 396 409 By similarity.
DISULFID 411 425 By similarity.
DISULFID 431 443 By similarity.
DISULFID 439 452 By similarity.
DISULFID 454 467 By similarity.
Amino Acid Sequence for C1QR1_HUMAN » Complement component C1q receptor
MATSMGLLLL LLLLLTQPGA GTGADTEAVV CVGTACYTAH SGKLSAAEAQ NHCNQNGGNL ATVKSKEEAQ HVQRVLAQLL RREAALTARM SKFWIGLQRE KGKCLDPSLP LKGFSWVGGG EDTPYSNWHK ELRNSCISKR CVSLLLDLSQ PLLPSRLPKW SEGPCGSPGS PGSNIEGFVC KFSFKGMCRP LALGGPGQVT YTTPFQTTSS SLEAVPFASA ANVACGEGDK DETQSHYFLC KEKAPDVFDW GSSGPLCVSP KYGCNFNNGG CHQDCFEGGD GSFLCGCRPG FRLLDDLVTC ASRNPCSSSP CRGGATCVLG PHGKNYTCRC PQGYQLDSSQ LDCVDVDECQ DSPCAQECVN TPGGFRCECW VGYEPGGPGE GACQDVDECA LGRSPCAQGC TNTDGSFHCS CEEGYVLAGE DGTQCQDVDE CVGPGGPLCD SLCFNTQGSF HCGCLPGWVL APNGVSCTMG PVSLGPPSGP PDEEDKGEKE GSTVPRAATA SPTRGPEGTP KATPTTSRPS LSSDAPITSA PLKMLAPSGS PGVWREPSIH HATAASGPQE PAGGDSSVAT QNNDGTDGQK LLLFYILGTV VAILLLLALA LGLLVYRKRR AKREEKKEKK PQNAADSYSW VPERAESRAM ENQYSPTPGT DC