C163B_HUMAN » Scavenger receptor cysteine-rich type 1 protein M160

C163B_HUMAN » Scavenger receptor cysteine-rich type 1 protein M160
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
C163B_HUMAN » Scavenger receptor cysteine-rich type 1 protein M160 » CD163 antigen-like 1;
Hydrophobic Thickness 35.6 ± 2.2 Å
Tilt Angle 5 ± 5°
ΔGtransfer -27.1 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1360-1384 (1355-1389)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 51-148, PDBID: 2OY3, Subunit A, Seq Identity:40%, Scavenger receptor cysteine-rich domain

AA: 158-255, PDBID: 2OY3, Subunit A, Seq Identity:40%, Scavenger receptor cysteine-rich domain

AA: 265-362, PDBID: 5A2E, Subunit A, Seq Identity:41%, Scavenger receptor cysteine-rich domain

AA: 372-469, PDBID: 1BY2, Subunit A, Seq Identity:39%, Scavenger receptor cysteine-rich domain

AA: 479-576, PDBID: 5A2E, Subunit A, Seq Identity:45%, Scavenger receptor cysteine-rich domain

AA: 586-683, PDBID: 2OY3, Subunit A, Seq Identity:41%, Scavenger receptor cysteine-rich domain

AA: 693-790, PDBID: 5A2E, Subunit A, Seq Identity:39%, Scavenger receptor cysteine-rich domain

AA: 798-895, PDBID: 5A2E, Subunit A, Seq Identity:37%, Scavenger receptor cysteine-rich domain

AA: 903-1000, PDBID: 5A2E, Subunit A, Seq Identity:35%, Scavenger receptor cysteine-rich domain

AA: 1039-1136, PDBID: 5A2E, Subunit A, Seq Identity:54%, Scavenger receptor cysteine-rich domain

AA: 1146-1243, PDBID: 2OY3, Subunit A, Seq Identity:31%, Scavenger receptor cysteine-rich domain

AA: 1249-1346, PDBID: 5A2E, Subunit A, Seq Identity:52%, Scavenger receptor cysteine-rich domain

UniProt annotation for C163B_HUMAN » Scavenger receptor cysteine-rich type 1 protein M160
TISSUE SPECIFICITY: Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.
UniProt features for C163B_HUMAN » Scavenger receptor cysteine-rich type 1 protein M160
SIGNAL 1 40
CHAIN 41 1453 Scavenger receptor cysteine-rich type 1 protein M160.
DOMAIN 48 148 SRCR 1.
DOMAIN 155 255 SRCR 2.
DOMAIN 262 362 SRCR 3.
DOMAIN 369 469 SRCR 4.
DOMAIN 476 576 SRCR 5.
DOMAIN 583 683 SRCR 6.
DOMAIN 690 790 SRCR 7.
DOMAIN 795 895 SRCR 8.
DOMAIN 900 1000 SRCR 9.
DOMAIN 1036 1136 SRCR 10.
DOMAIN 1141 1243 SRCR 11.
DOMAIN 1246 1346 SRCR 12.
DISULFID 73 137 By similarity.
DISULFID 86 147 By similarity.
DISULFID 117 127 By similarity.
DISULFID 180 244 By similarity.
DISULFID 193 254 By similarity.
DISULFID 224 234 By similarity.
DISULFID 287 351 By similarity.
DISULFID 300 361 By similarity.
DISULFID 331 341 By similarity.
DISULFID 394 458 By similarity.
DISULFID 407 468 By similarity.
DISULFID 438 448 By similarity.
DISULFID 501 565 By similarity.
DISULFID 514 575 By similarity.
DISULFID 545 555 By similarity.
DISULFID 608 672 By similarity.
DISULFID 621 682 By similarity.
DISULFID 652 662 By similarity.
DISULFID 715 779 By similarity.
DISULFID 728 789 By similarity.
DISULFID 759 769 By similarity.
DISULFID 820 884 By similarity.
DISULFID 833 894 By similarity.
DISULFID 864 874 By similarity.
DISULFID 925 989 By similarity.
DISULFID 938 999 By similarity.
DISULFID 969 979 By similarity.
DISULFID 1061 1125 By similarity.
DISULFID 1074 1135 By similarity.
DISULFID 1105 1115 By similarity.
DISULFID 1181 1242 By similarity.
DISULFID 1212 1222 By similarity.
DISULFID 1271 1335 By similarity.
DISULFID 1284 1345 By similarity.
DISULFID 1315 1325 By similarity.
Amino Acid Sequence for C163B_HUMAN » Scavenger receptor cysteine-rich type 1 protein M160
MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPMHVFGMTY FKEASGPIWL DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANGWG MNIAEVVCRQ LECGSAIRVS REPHFTERTL HILMSNSGCT GGEASLWDCI RWEWKQTACH LNMEASLICS AHRQPRLVGA DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD AISLSVGDHF GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT GGKYIGERSV RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT GSLTQPLFPC LANVSDPYLS AVPEGSALIC LEDKRLRLVD GDSRCAGRVE IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG VAFNATVSAH FGEGSGPIWL DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA LRLYSETETE SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSTAEETWI TCEDRIRVRG GDTECSGRVE IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS FGQGTGTIWL DDMRCKGNES FLWDCHAKPW GQSDCGHKED AGVRCSGQSL KSLNASSGRL ALILSSIFGL LLPVLFILFL TWCRVQKQKH LPLRVSTRRR GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT SLLGVLPASE ATK