BTNL8_HUMAN » Butyrophilin-like protein 8

BTNL8_HUMAN » Butyrophilin-like protein 8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BTNL8_HUMAN » Butyrophilin-like protein 8 »
Hydrophobic Thickness 34.4 ± 1.4 Å
Tilt Angle 33 ± 0°
ΔGtransfer -25.5 kcal/mol
ΔGfold -11.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 233-259 (230-261)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 23-132, PDBID: 4F8T, Subunit A, Seq Identity:35%, Immunoglobulin V-set domain

AA: 290-336, PDBID: 4N7I, Subunit A, Seq Identity:44%, SPRY-associated domain

AA: 340-457, PDBID: 4N7I, Subunit A, Seq Identity:41%, SPRY domain

UniProt annotation for BTNL8_HUMAN » Butyrophilin-like protein 8
FUNCTION: May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.

TISSUE SPECIFICITY: Expressed in neutrophils. Isoforms 1 and 5 are expressed at high levels in the colon, lung,testis, lymph nodes and thyroid tissue. Isoform 5, but not isoform 1, is detected in spleen.

INDUCTION: Down-regulated in neutrophils after treatment with LPS and TNF.

UniProt features for BTNL8_HUMAN » Butyrophilin-like protein 8
SIGNAL 1 17
CHAIN 18 500 Butyrophilin-like protein 8.
DOMAIN 19 132 Ig-like V-type 1.
DOMAIN 133 222 Ig-like V-type 2.
DOMAIN 270 466 B30.2/SPRY.
DISULFID 40 114 By similarity.
DISULFID 154 206 By similarity.
Amino Acid Sequence for BTNL8_HUMAN » Butyrophilin-like protein 8
MALMLSLVLS LLKLGSGQWQ VFGPDKPVQA LVGEDAAFSC FLSPKTNAEA MEVRFFRGQF SSVVHLYRDG KDQPFMQMPQ YQGRTKLVKD SIAEGRISLR LENITVLDAG LYGCRISSQS YYQKAIWELQ VSALGSVPLI SITGYVDRDI QLLCQSSGWF PRPTAKWKGP QGQDLSTDSR TNRDMHGLFD VEISLTVQEN AGSISCSMRH AHLSREVESR VQIGDTFFEP ISWHLATKVL GILCCGLFFG IVGLKIFFSK FQWKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQSFQAGK HYWEVDGGHN KRWRVGVCRD DVDRRKEYVT LSPDHGYWVL RLNGEHLYFT LNPRFISVFP RTPPTKIGVF LDYECGTISF FNINDQSLIY TLTCRFEGLL RPYIEYPSYN EQNGTPIVIC PVTQESEKEA SWQRASAIPE TSNSESSSQA TTPFLPRGEM