BTLA_HUMAN » B- and T-lymphocyte attenuator

BTLA_HUMAN » B- and T-lymphocyte attenuator
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BTLA_HUMAN » B- and T-lymphocyte attenuator » B- and T-lymphocyte-associated protein;
Hydrophobic Thickness 34.8 ± 2.6 Å
Tilt Angle 6 ± 3°
ΔGtransfer -23.3 kcal/mol
ΔGfold -8.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 153-178 (152-181)
Pathways

Immune System (Reactome)

PDB 2aw2 (A/X=26-137)
OPM none
Complexes

BTLA:TNR14_HUMAN

Interactions

CD19, Complex: CD79A:CD19:CD79B:BTLA

CD79A, Complex: CD79B:BTLA:CD79A:CD19

CD79B, Complex: CD79B:BTLA:CD79A:CD19

TNR14, Complex: BTLA:TNR14, PDBID: 2aw2, PubMed

VTCN1, Complex: BTLA:VTCN1, PubMed

Domains

AA: 41-130, PDBID: 2AW2, Subunit X, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for BTLA_HUMAN » B- and T-lymphocyte attenuator
FUNCTION: Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.

SUBUNIT: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.

UniProt features for BTLA_HUMAN » B- and T-lymphocyte attenuator
SIGNAL 1 30 Potential.
CHAIN 31 289 B- and T-lymphocyte attenuator.
DOMAIN 43 134 Ig-like V-type.
DISULFID 34 63
DISULFID 58 115
DISULFID 72 79
Amino Acid Sequence for BTLA_HUMAN » B- and T-lymphocyte attenuator
MKTLPAMLGT GKLFWVFFLI PYLDIWNIHG KESCDVQLYI KRQSEHSILA GDPFELECPV KYCANRPHVT WCKLNGTTCV KLEDRQTSWK EEKNISFFIL HFEPVLPNDN GSYRCSANFQ SNLIESHSTT LYVTDVKSAS ERPSKDEMAS RPWLLYSLLP LGGLPLLITT CFCLFCCLRR HQGKQNELSD TAGREINLVD AHLKSEQTEA STRQNSQVLL SETGIYDNDP DLCFRMQEGS EVYSNPCLEE NKPGIVYASL NHSVIGLNSR LARNVKEAPT EYASICVRS