BTC_HUMAN » Probetacellulin

BTC_HUMAN » Probetacellulin
Magnify BTC_HUMAN » ProbetacellulinEnlarged view of image
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BTC_HUMAN » Probetacellulin »
Hydrophobic Thickness 34.8 ± 2.8 Å
Tilt Angle 1 ± 12°
ΔGtransfer -29.7 kcal/mol
ΔGfold -21.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 117-140 (115-143)
Pathways

ErbB signaling pathway (KEGG)

Immune System (Reactome)

Signal Transduction (Reactome)

PDB 1iox (62-111), 1ip0 (62-111)
OPM none
Complexes none
Interactions

EGFR, Complex: EGFR:BTC, PubMed

ERBB2, Complex: BTC:ERBB2, PubMed

ERBB4, Complex: ERBB4:BTC, PubMed

Domains none
UniProt annotation for BTC_HUMAN » Probetacellulin
FUNCTION: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

SUBUNIT: Monomer. Interacts with EGFR and ERBB4.

TISSUE SPECIFICITY: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.

UniProt features for BTC_HUMAN » Probetacellulin
SIGNAL 1 31 By similarity.
CHAIN 32 178 Probetacellulin.
CHAIN 32 111 Betacellulin.
PROPEP 112 178 Removed in mature form (By similarity).
DOMAIN 65 105 EGF-like.
DISULFID 69 82
DISULFID 77 93
DISULFID 95 104
Amino Acid Sequence for BTC_HUMAN » Probetacellulin
MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE ENCAATTTQS KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF YLRGDRGQIL VICLIAVMVV FIILVIGVCT CCHPLRKRRK RKKKEEEMET LGKDITPINE DIEETNIA