BT3A3_HUMAN » Butyrophilin subfamily 3 member A3

BT3A3_HUMAN » Butyrophilin subfamily 3 member A3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BT3A3_HUMAN » Butyrophilin subfamily 3 member A3 »
Hydrophobic Thickness 30.8 ± 2.0 Å
Tilt Angle 6 ± 3°
ΔGtransfer -30.9 kcal/mol
ΔGfold -15.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 245-270 (245-276)
Pathways none
PDB 4f8t (A=30-246)
OPM none
Complexes none
Interactions none
Domains

AA: 35-144, PDBID: 4F8T, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 342-390, PDBID: 4N7I, Subunit A, Seq Identity:86%, SPRY-associated domain

AA: 394-507, PDBID: 4N7I, Subunit A, Seq Identity:83%, SPRY domain

UniProt annotation for BT3A3_HUMAN » Butyrophilin subfamily 3 member A3
FUNCTION: Plays a role in T-cell responses in the adaptive immune response.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected in spleen and lymphocytes.

UniProt features for BT3A3_HUMAN » Butyrophilin subfamily 3 member A3
SIGNAL 1 29
CHAIN 30 584 Butyrophilin subfamily 3 member A3.
DOMAIN 30 139 Ig-like V-type 1.
DOMAIN 145 236 Ig-like V-type 2.
DOMAIN 322 518 B30.2/SPRY.
DISULFID 52 126
DISULFID 166 220
Amino Acid Sequence for BT3A3_HUMAN » Butyrophilin subfamily 3 member A3
MKMASSLAFL LLNFHVSLFL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELRWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSDL HIEVKGYEDG GIHLECRSTG WYPQPQIKWS DTKGENIPAV EAPVVADGVG LYAVAASVIM RGSSGGGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA ALAGTLPISL LLLAGASYFL WRQQKEKIAL SRETEREREM KEMGYAATEQ EISLREKLQE ELKWRKIQYM ARGEKSLAYH EWKMALFKPA DVILDPDTAN AILLVSEDQR SVQRAEEPRD LPDNPERFEW RYCVLGCENF TSGRHYWEVE VGDRKEWHIG VCSKNVERKK GWVKMTPENG YWTMGLTDGN KYRALTEPRT NLKLPEPPRK VGIFLDYETG EISFYNATDG SHIYTFPHAS FSEPLYPVFR ILTLEPTALT ICPIPKEVES SPDPDLVPDH SLETPLTPGL ANESGEPQAE VTSLLLPAHP GAEVSPSATT NQNHKLQART EALY