BT3A2_HUMAN » Butyrophilin subfamily 3 member A2

BT3A2_HUMAN » Butyrophilin subfamily 3 member A2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BT3A2_HUMAN » Butyrophilin subfamily 3 member A2 »
Hydrophobic Thickness 34.8 ± 3.2 Å
Tilt Angle 24 ± 12°
ΔGtransfer -20.6 kcal/mol
ΔGfold -18.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 245-270 (245-276)
Pathways none
PDB 4f8q (A=30-239)
OPM none
Complexes none
Interactions none
Domains

AA: 35-144, PDBID: 4F80, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for BT3A2_HUMAN » Butyrophilin subfamily 3 member A2
FUNCTION: Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Detected in T-cells and natural killer cells.

UniProt features for BT3A2_HUMAN » Butyrophilin subfamily 3 member A2
SIGNAL 1 29 Potential.
CHAIN 30 334 Butyrophilin subfamily 3 member A2.
DOMAIN 30 139 Ig-like V-type.
COILED 272 319 Potential.
DISULFID 52 126
DISULFID 166 220
Amino Acid Sequence for BT3A2_HUMAN » Butyrophilin subfamily 3 member A2
MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSNL HVEVKGYEDG GIHLECRSTG WYPQPQIQWS NAKGENIPAV EAPVVADGVG LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA