BT3A1_HUMAN » Butyrophilin subfamily 3 member A1

BT3A1_HUMAN » Butyrophilin subfamily 3 member A1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BT3A1_HUMAN » Butyrophilin subfamily 3 member A1 »
Hydrophobic Thickness 34.0 ± 2.0 Å
Tilt Angle 3 ± 3°
ΔGtransfer -43.1 kcal/mol
ΔGfold -14.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 245-270 (244-277)
Pathways none
PDB 4jkw (28-143), 4k55 (28-143), 4f9l (A/B=30-246), 4f9p (A/B=30-246), 4f80 (A=30-246), 4n7i (A=328-513), 4n7u (A=328-513)
OPM none
Complexes

BT3A1:BT3A1_HUMAN

Interactions

BT3A1, Complex: Homodimer of BTN3A1 ectodomain, PDBID: 4F9L

Domains

AA: 35-144, PDBID: 4F80, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 342-390, PDBID: 4N7I, Subunit A, Seq Identity:100%, SPRY-associated domain

AA: 394-506, PDBID: 4N7I, Subunit A, Seq Identity:100%, SPRY domain

UniProt annotation for BT3A1_HUMAN » Butyrophilin subfamily 3 member A1
FUNCTION: Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle.

UniProt features for BT3A1_HUMAN » Butyrophilin subfamily 3 member A1
SIGNAL 1 29 Potential.
CHAIN 30 513 Butyrophilin subfamily 3 member A1.
DOMAIN 30 139 Ig-like V-type 1.
DOMAIN 145 236 Ig-like V-type 2.
DOMAIN 322 513 B30.2/SPRY.
DISULFID 52 126
DISULFID 166 220
Amino Acid Sequence for BT3A1_HUMAN » Butyrophilin subfamily 3 member A1
MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP FFRSAQRWIA ALAGTLPVLL LLLGGAGYFL WQQQEEKKTQ FRKKKREQEL REMAWSTMKQ EQSTRVKLLE ELRWRSIQYA SRGERHSAYN EWKKALFKPA DVILDPKTAN PILLVSEDQR SVQRAKEPQD LPDNPERFNW HYCVLGCESF ISGRHYWEVE VGDRKEWHIG VCSKNVQRKG WVKMTPENGF WTMGLTDGNK YRTLTEPRTN LKLPKPPKKV GVFLDYETGD ISFYNAVDGS HIHTFLDVSF SEALYPVFRI LTLEPTALTI CPA