BT2A2_HUMAN » Butyrophilin subfamily 2 member A2

BT2A2_HUMAN » Butyrophilin subfamily 2 member A2
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
BT2A2_HUMAN » Butyrophilin subfamily 2 member A2 »
Hydrophobic Thickness 33.2 ± 1.8 Å
Tilt Angle 3 ± 0°
ΔGtransfer -41.6 kcal/mol
ΔGfold -22.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 264-286 (264-293)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CREB3, Complex: BT2A2:CREB3

FATE1, Complex: BT2A2:FATE1

Domains

AA: 38-147, PDBID: 4F8T, Subunit A, Seq Identity:50%, Immunoglobulin V-set domain

AA: 329-377, PDBID: 2IWG, Subunit E, Seq Identity:62%, SPRY-associated domain

AA: 381-497, PDBID: 2IWG, Subunit E, Seq Identity:51%, SPRY domain

UniProt annotation for BT2A2_HUMAN » Butyrophilin subfamily 2 member A2
FUNCTION: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

TISSUE SPECIFICITY: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.

UniProt features for BT2A2_HUMAN » Butyrophilin subfamily 2 member A2
SIGNAL 1 32 Potential.
CHAIN 33 523 Butyrophilin subfamily 2 member A2.
DOMAIN 34 145 Ig-like V-type.
DOMAIN 153 234 Ig-like C2-type.
DOMAIN 309 502 B30.2/SPRY.
COILED 286 321 Potential.
DISULFID 55 129 By similarity.
Amino Acid Sequence for BT2A2_HUMAN » Butyrophilin subfamily 2 member A2
MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN TTLRCHLSPE KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI TFVSKDINRG SVALVIHNVT AQENGIYRCY FQEGRSYDEA ILRLVVAGLG SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT VWRDPYGEVV PALKEVSIAD ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI PESFMPSASP WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR RGPYRQRVPD NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR HSVERKGEVL LIPQNGFWTL EMFGNQYRAL SSPERILPLK ESLCRVGVFL DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV RPFFRLGSDD SPIFICPALT GASGVMVPEE GLKLHRVGTH QSL