BT2A1_HUMAN » Butyrophilin subfamily 2 member A1

BT2A1_HUMAN » Butyrophilin subfamily 2 member A1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BT2A1_HUMAN » Butyrophilin subfamily 2 member A1 »
Hydrophobic Thickness 36.4 ± 2.2 Å
Tilt Angle 5 ± 1°
ΔGtransfer -29.5 kcal/mol
ΔGfold -17.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 246-269 (246-276)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 34-143, PDBID: 4F8T, Subunit A, Seq Identity:49%, Immunoglobulin V-set domain

AA: 330-381, PDBID: 2IWG, Subunit E, Seq Identity:56%, SPRY-associated domain

AA: 385-500, PDBID: 2IWG, Subunit E, Seq Identity:52%, SPRY domain

UniProt annotation for BT2A1_HUMAN » Butyrophilin subfamily 2 member A1
TISSUE SPECIFICITY: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.
UniProt features for BT2A1_HUMAN » Butyrophilin subfamily 2 member A1
SIGNAL 1 28 Potential.
CHAIN 29 527 Butyrophilin subfamily 2 member A1.
DOMAIN 29 141 Ig-like V-type.
DOMAIN 310 506 B30.2/SPRY.
DISULFID 51 125 By similarity.
Amino Acid Sequence for BT2A1_HUMAN » Butyrophilin subfamily 2 member A1
MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF MPSVSPCAVA LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE RVQKEEELQV KEKLQEELRW RRTFLHAVDV VLDPDTAHPD LFLSEDRRSV RRCPFRHLGE SVPDNPERFD SQPCVLGRES FASGKHYWEV EVENVIEWTV GVCRDSVERK GEVLLIPQNG FWTLEMHKGQ YRAVSSPDRI LPLKESLCRV GVFLDYEAGD VSFYNMRDRS HIYTCPRSAF SVPVRPFFRL GCEDSPIFIC PALTGANGVT VPEEGLTLHR VGTHQSL