BT1A1_HUMAN » Butyrophilin subfamily 1 member A1

BT1A1_HUMAN » Butyrophilin subfamily 1 member A1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BT1A1_HUMAN » Butyrophilin subfamily 1 member A1 » BT;
Hydrophobic Thickness 41.6 ± 5.0 Å
Tilt Angle 1 ± 1°
ΔGtransfer -29.5 kcal/mol
ΔGfold -23.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 243-271 (243-272)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 33-142, PDBID: 4HH8, Subunit A, Seq Identity:75%, Immunoglobulin V-set domain

AA: 146-229, PDBID: 4HH8, Subunit A, Seq Identity:66%, CD80-like C2-set immunoglobulin domain

AA: 305-353, PDBID: 2IWG, Subunit E, Seq Identity:58%, SPRY-associated domain

AA: 357-472, PDBID: 4N7I, Subunit A, Seq Identity:64%, SPRY domain

UniProt annotation for BT1A1_HUMAN » Butyrophilin subfamily 1 member A1
FUNCTION: May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).

SUBUNIT: Seems to associate with xanthine dehydrogenase/oxidase.

UniProt features for BT1A1_HUMAN » Butyrophilin subfamily 1 member A1
SIGNAL 1 26 By similarity.
CHAIN 27 526 Butyrophilin subfamily 1 member A1.
DOMAIN 27 138 Ig-like V-type 1.
DOMAIN 148 234 Ig-like V-type 2.
DOMAIN 285 479 B30.2/SPRY.
DISULFID 50 124 By similarity.
DISULFID 164 218 By similarity.
Amino Acid Sequence for BT1A1_HUMAN » Butyrophilin subfamily 1 member A1
MAVFPSSGLP RCLLTLILLQ LPKLDSAPFD VIGPPEPILA VVGEDAELPC RLSPNASAEH LELRWFRKKV SPAVLVHRDG REQEAEQMPE YRGRATLVQD GIAKGRVALR IRGVRVSDDG EYTCFFREDG SYEEALVHLK VAALGSDPHI SMQVQENGEI CLECTSVGWY PEPQVQWRTS KGEKFPSTSE SRNPDEEGLF TVAASVIIRD TSTKNVSCYI QNLLLGQEKK VEISIPASSL PRLTPWIVAV AVILMVLGLL TIGSIFFTWR LYNERPRERR NEFSSKERLL EELKWKKATL HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKTER FDSWPCVLGR ETFTSGRHYW EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG NGYWALTPLR TPLPLAGPPR RVGIFLDYES GDISFYNMND GSDIYTFSNV TFSGPLRPFF CLWSSGKKPL TICPIADGPE RVTVIANAQD LSKEIPLSPM GEDSAPRDAD TLHSKLIPTQ PSQGAP