BRL2_ARATH » Serine/threonine-protein kinase BRI1-like 2

BRL2_ARATH » Serine/threonine-protein kinase BRI1-like 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BRL2_ARATH » Serine/threonine-protein kinase BRI1-like 2 » BRASSINOSTEROID INSENSITIVE 1-like protein 2;Protein VASCULAR HIGHWAY 1;
Hydrophobic Thickness 38.4 ± 1.2 Å
Tilt Angle 7 ± 5°
ΔGtransfer -48.1 kcal/mol
ΔGfold -19.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 755-780 (750-782)
Pathways none
PDB none
OPM none
Complexes none
Interactions

B3GT4, Complex: BRL2:B3GT4

Domains

AA: 36-76, PDBID: 3RGX, Subunit A, Seq Identity:43%, Leucine rich repeat N-terminal domain

AA: 128-190, PDBID: 4BSR, Subunit B, Seq Identity:36%, Leucine rich repeat

AA: 202-264, PDBID: 4MN8, Subunit A, Seq Identity:45%, Leucine rich repeat

AA: 277-338, PDBID: 4M7E, Subunit C, Seq Identity:44%, Leucine rich repeat

AA: 838-1125, PDBID: 4OA2, Subunit A, Seq Identity:66%, Protein kinase domain

UniProt annotation for BRL2_ARATH » Serine/threonine-protein kinase BRI1-like 2
FUNCTION: Receptor with a serine/threonine-protein kinase activity, which may transduce extracellular spatial and temporal signals into downstream cell differentiation responses in provascular and procambial cells. In contrast to BRI1, BRL1 and BRL3, it does not bind brassinolide.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Interacts with TTL3.

TISSUE SPECIFICITY: Expressed in provascular and procambial sites throughout plant development. Expressed throughout globe- to heart-staged embryos. Then, it is restricted to procambial cells by the late torpedo stage, and this pattern persists throughout the duration of embryo development. After germination, it is expressed not only in procambial cells throughout the plant but also in all lateral organ primordia before the onset of vascularization.

DOMAIN: Contains two pairs of conservatively spaced Cys (Cys pair 1 and 2) possibly involved in forming some heterodimers.

UniProt features for BRL2_ARATH » Serine/threonine-protein kinase BRI1-like 2
SIGNAL 1 31 Potential.
CHAIN 32 1143 Serine/threonine-protein kinase BRI1-like 2.
REPEAT 79 100 LRR 1.
REPEAT 104 126 LRR 2.
REPEAT 128 150 LRR 3.
REPEAT 153 175 LRR 4.
REPEAT 178 200 LRR 5.
REPEAT 205 228 LRR 6.
REPEAT 229 251 LRR 7.
REPEAT 253 275 LRR 8.
REPEAT 278 299 LRR 9.
REPEAT 302 323 LRR 10.
REPEAT 327 349 LRR 11.
REPEAT 351 372 LRR 12.
REPEAT 376 398 LRR 13.
REPEAT 400 422 LRR 14.
REPEAT 424 446 LRR 15.
REPEAT 448 470 LRR 16.
REPEAT 472 494 LRR 17.
REPEAT 496 518 LRR 18.
REPEAT 520 542 LRR 19.
REPEAT 612 634 LRR 20.
REPEAT 636 658 LRR 21.
REPEAT 660 682 LRR 22.
REPEAT 684 706 LRR 23.
DOMAIN 838 1129 Protein kinase.
MOTIF 68 75 Cys pair 1.
MOTIF 720 727 Cys pair 2.
ACT_SITE 966 966 Proton acceptor (By similarity).
Amino Acid Sequence for BRL2_ARATH » Serine/threonine-protein kinase BRI1-like 2
MTTSPIRVRI RTRIQISFIF LLTHLSQSSS SDQSSLKTDS LSLLSFKTMI QDDPNNILSN WSPRKSPCQF SGVTCLGGRV TEINLSGSGL SGIVSFNAFT SLDSLSVLKL SENFFVLNST SLLLLPLTLT HLELSSSGLI GTLPENFFSK YSNLISITLS YNNFTGKLPN DLFLSSKKLQ TLDLSYNNIT GPISGLTIPL SSCVSMTYLD FSGNSISGYI SDSLINCTNL KSLNLSYNNF DGQIPKSFGE LKLLQSLDLS HNRLTGWIPP EIGDTCRSLQ NLRLSYNNFT GVIPESLSSC SWLQSLDLSN NNISGPFPNT ILRSFGSLQI LLLSNNLISG DFPTSISACK SLRIADFSSN RFSGVIPPDL CPGAASLEEL RLPDNLVTGE IPPAISQCSE LRTIDLSLNY LNGTIPPEIG NLQKLEQFIA WYNNIAGEIP PEIGKLQNLK DLILNNNQLT GEIPPEFFNC SNIEWVSFTS NRLTGEVPKD FGILSRLAVL QLGNNNFTGE IPPELGKCTT LVWLDLNTNH LTGEIPPRLG RQPGSKALSG LLSGNTMAFV RNVGNSCKGV GGLVEFSGIR PERLLQIPSL KSCDFTRMYS GPILSLFTRY QTIEYLDLSY NQLRGKIPDE IGEMIALQVL ELSHNQLSGE IPFTIGQLKN LGVFDASDNR LQGQIPESFS NLSFLVQIDL SNNELTGPIP QRGQLSTLPA TQYANNPGLC GVPLPECKNG NNQLPAGTEE GKRAKHGTRA ASWANSIVLG VLISAASVCI LIVWAIAVRA RRRDADDAKM LHSLQAVNSA TTWKIEKEKE PLSINVATFQ RQLRKLKFSQ LIEATNGFSA ASMIGHGGFG EVFKATLKDG SSVAIKKLIR LSCQGDREFM AEMETLGKIK HRNLVPLLGY CKIGEERLLV YEFMQYGSLE EVLHGPRTGE KRRILGWEER KKIAKGAAKG LCFLHHNCIP HIIHRDMKSS NVLLDQDMEA RVSDFGMARL ISALDTHLSV STLAGTPGYV PPEYYQSFRC TAKGDVYSIG VVMLEILSGK RPTDKEEFGD TNLVGWSKMK AREGKHMEVI DEDLLKEGSS ESLNEKEGFE GGVIVKEMLR YLEIALRCVD DFPSKRPNML QVVASLRELR GSENNSHSHS NSL