BNIP3_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

BNIP3_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Magnify BNIP3_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
BNIP3_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 »
Hydrophobic Thickness 31.2 ± 0.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -36.5 kcal/mol
ΔGfold -9.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 160-183 (158-187)
Pathways

Legionellosis (KEGG)

PDB 2j5d (A/B=146-190), 2ka1 (A/B=154-188), 2ka2 (A/B=154-188)
OPM 2j5d, 2ka1, 2ka2
Complexes

BNIP3:BNIP3_HUMAN

Interactions

B2CL1, Complex: B2CL1:BNIP3, PubMed

BCL2, Complex: BCL2:BNIP3, PubMed

BNI3L, Complex: BNIP3:BNI3L, PubMed

BNIP3, Complex: Transmembrane homodimer of BNIP3, PDBID: 2J5D

CLC7A, Complex: BNIP3:CLC7A

CREB3, Complex: BNIP3:CREB3

FATE1, Complex: BNIP3:FATE1

KTN1, Complex: KTN1:BNIP3

LRAD1, Complex: BNIP3:LRAD1

Domains

AA: 2-193, PDBID: 2J5D, Subunit A, Seq Identity:100%, BNIP3

UniProt annotation for BNIP3_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
FUNCTION: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

SUBUNIT: Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).

UniProt features for BNIP3_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
CHAIN 1 194 BCL2/adenovirus E1B 19 kDa protein- interacting protein 3.
MOTIF 100 125 BH3.
Amino Acid Sequence for BNIP3_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG IYIGRRLTTS TSTF