BNI3L_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

BNI3L_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
BNI3L_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like » Adenovirus E1B19K-binding protein B5;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A;NIP3-like protein X;NIP3L;
Hydrophobic Thickness 30.4 ± 1.0 Å
Tilt Angle 2 ± 0°
ΔGtransfer -34.5 kcal/mol
ΔGfold -8.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 185-207 (182-211)
Pathways none
PDB none
OPM none
Complexes none
Interactions

B2CL1, Complex: BNI3L:B2CL1, PubMed

BCL2, Complex: BCL2:BNI3L, PubMed

BNIP3, Complex: BNIP3:BNI3L, PubMed

CK075, Complex: BNI3L:SMCO4

CLC7A, Complex: BNI3L:CLC7A

FATE1, Complex: BNI3L:FATE1

LRAD1, Complex: BNI3L:LRAD1

ROBO2, Complex: BNI3L:ROBO2, PubMed

Domains

AA: 15-218, PDBID: 2J5D, Subunit A, Seq Identity:53%, BNIP3

UniProt annotation for BNI3L_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
FUNCTION: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

SUBUNIT: Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).

UniProt features for BNI3L_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
CHAIN 1 219 BCL2/adenovirus E1B 19 kDa protein- interacting protein 3-like.
MOTIF 126 148 BH3.
Amino Acid Sequence for BNI3L_HUMAN » BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSRDHSSQS EEEVVEGEKE VEALKKSADW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY