BCAM_HUMAN » Basal cell adhesion molecule

BCAM_HUMAN » Basal cell adhesion molecule
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BCAM_HUMAN » Basal cell adhesion molecule » Auberger B antigen;B-CAM cell surface glycoprotein;F8/G253 antigen;Lutheran antigen;Lutheran blood group glycoprotein;
Hydrophobic Thickness 38.8 ± 2.2 Å
Tilt Angle 0 ± 3°
ΔGtransfer -56.5 kcal/mol
ΔGfold -20.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 544-572 (542-574)
Pathways none
PDB 2pet (32-262), 2pf6 (32-262)
OPM none
Complexes none
Interactions none
Domains

AA: 36-144, PDBID: 2PET, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 150-248, PDBID: 2PET, Subunit A, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

AA: 271-341, PDBID: 3K0W, Subunit A, Seq Identity:32%, Immunoglobulin domain

AA: 367-442, PDBID: 3WO4, Subunit C, Seq Identity:28%, Immunoglobulin domain

AA: 453-538, PDBID: 3NVQ, Subunit A, Seq Identity:27%, Immunoglobulin domain

UniProt annotation for BCAM_HUMAN » Basal cell adhesion molecule
FUNCTION: Laminin alpha-5 receptor. May mediate intracellular signaling.

TISSUE SPECIFICITY: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

DEVELOPMENTAL STAGE: Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up- regulated following malignant transformation in some cell types.

UniProt features for BCAM_HUMAN » Basal cell adhesion molecule
SIGNAL 1 31
CHAIN 32 628 Basal cell adhesion molecule.
DOMAIN 32 142 Ig-like V-type 1.
DOMAIN 147 257 Ig-like V-type 2.
DOMAIN 274 355 Ig-like C2-type 1.
DOMAIN 363 441 Ig-like C2-type 2.
DOMAIN 448 541 Ig-like C2-type 3.
REGION 309 312 Interaction with laminin alpha5.
DISULFID 53 125
DISULFID 172 237
DISULFID 291 337 Probable.
DISULFID 384 424 Probable.
DISULFID 473 522 Probable.
Amino Acid Sequence for BCAM_HUMAN » Basal cell adhesion molecule
MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI LDCTPTGTHD HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP PYQLDSQGRL VLAEAQVGDE RDYVCVVRAG AAGTAEATAR LNVFAKPEAT EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA PKITWYRNGQ RLEVPVEMNP EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH YSLPEGRHGR LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL SKTLELRVAY LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS TPLGDGPMLS LSSITFDSNG TYVCEASLPT VPVLSRTQNF TLLVQGSPEL KTAEIEPKAD GSWREGDEVT LICSARGHPD PKLSWSQLGG SPAEPIPGRQ GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV SPQTSQAGVA VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS EQPEQTGLLM GGASGGARGG SGGFGDEC