BASI_HUMAN » Basigin

BASI_HUMAN » Basigin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BASI_HUMAN » Basigin » 5F7;Collagenase stimulatory factor;Extracellular matrix metalloproteinase inducer;EMMPRIN; Leukocyte activation antigen M6;OK blood group antigen;Tumor cell-derived collagenase stimulatory factor;TCSF;
Hydrophobic Thickness 36.0 ± 3.0 Å
Tilt Angle 7 ± 2°
ΔGtransfer -30.2 kcal/mol
ΔGfold -17.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 322-347 (316-350)
Pathways

Hemostasis (Reactome)

Signal Transduction (Reactome)

PDB 3i85 (13-219), 3b5h (140-321), 3i84 (A/B=13-219), 3qqn (A/B=23-138), 3qr2 (A/B=23-138), 4u0q (B/D=1-385)
OPM none
Complexes

BASI:BASI_HUMAN

Interactions

BASI, Complex: Homodimer of basigin, PDBID: 3QQN

ITA3, Complex: ITA3:BASI:ITB1, PubMed

ITA6, Complex: ITB1:BASI:ITA6, PubMed

NICA, Complex: PEN2:BASI:APH1A:PSN1:NICA

SE1L1, Complex: SE1L1:BASI, PubMed

Domains

AA: 25-112, PDBID: 3QQN, Subunit B, Seq Identity:100%, Immunoglobulin domain

AA: 220-305, PDBID: 3B5H, Subunit B, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for BASI_HUMAN » Basigin
FUNCTION: Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

SUBUNIT: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane.

TISSUE SPECIFICITY: Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

INDUCTION: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

UniProt features for BASI_HUMAN » Basigin
SIGNAL 1 21
CHAIN 22 385 Basigin.
DOMAIN 138 219 Ig-like C2-type.
DOMAIN 221 315 Ig-like V-type.
DISULFID 157 203
DISULFID 242 301
Amino Acid Sequence for BASI_HUMAN » Basigin
MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA GSAPLKSSGQ HQNDKGKNVR QRNSS