BAME1_ARATH » Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1

BAME1_ARATH » Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BAME1_ARATH » Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1 » Protein BARELY ANY MERISTEM 1;
Hydrophobic Thickness 39.2 ± 4.0 Å
Tilt Angle 2 ± 0°
ΔGtransfer -29.2 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 639-665 (638-672)
Pathways

Starch and sucrose metabolism (KEGG)

PDB none
OPM none
Complexes none
Interactions

CLV1, Complex: BAME1:CLV1

Domains

AA: 22-65, PDBID: 4M7E, Subunit D, Seq Identity:41%, Leucine rich repeat N-terminal domain

AA: 142-187, PDBID: 3RGX, Subunit A, Seq Identity:37%, Leucine Rich repeats (2 copies)

AA: 694-965, PDBID: 3TL8, Subunit A, Seq Identity:39%, Protein kinase domain

UniProt annotation for BAME1_ARATH » Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1
FUNCTION: Necessary for male gametophyte development, as well as ovule specification and function. Involved in cell-cell communication process required during early anther development, and regulating cell division and differentiation to organize cell layers. Required for the development of high-ordered vascular strands within the leaf and a correlated control of leaf shape, size and symmetry. May regulate the CLV1-dependent CLV3-mediated signaling in meristems maintenance.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Self-interacts and interacts with BAM2 and CLV1. Binds to the CLV3, CLE5, CLE11, CLE18, CLE19, CLE22, CLE25, CLE26, CLE40, CLE41 and CLE42 mature peptides, probably via its extracellular leucine-rich repeat region.

TISSUE SPECIFICITY: Expressed in seedlings, roots, leaves, inflorescences, flowers and siliques.

DEVELOPMENTAL STAGE: Expressed in a ring surrounding the center of meristems extended in the cortex of developing stems and older pedicels. Present in all developing floral organs, especially in anthers and gynoecium. Observed in anthers at stage 2 in the archesporial cells. At stage 3, localized in the primary sporogenous and primary parietal cells. Subsequently preferentially expressed in the sporogenous cells at anther stage 4. Later restricted to the tapetum and pollen mother cells (PMCs) before disappearing progressively.

UniProt features for BAME1_ARATH » Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1
SIGNAL 1 19 Potential.
CHAIN 20 1003 Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1.
REPEAT 68 92 LRR 1.
REPEAT 93 116 LRR 2.
REPEAT 117 140 LRR 3.
REPEAT 142 165 LRR 4.
REPEAT 166 191 LRR 5.
REPEAT 193 213 LRR 6.
REPEAT 215 238 LRR 7.
REPEAT 239 262 LRR 8.
REPEAT 263 285 LRR 9.
REPEAT 286 310 LRR 10.
REPEAT 312 334 LRR 11.
REPEAT 335 358 LRR 12.
REPEAT 359 382 LRR 13.
REPEAT 385 406 LRR 14.
REPEAT 407 430 LRR 15.
REPEAT 432 454 LRR 16.
REPEAT 455 480 LRR 17.
REPEAT 482 502 LRR 18.
REPEAT 503 526 LRR 19.
REPEAT 527 550 LRR 20.
REPEAT 551 574 LRR 21.
REPEAT 575 598 LRR 22.
DOMAIN 694 971 Protein kinase.
ACT_SITE 820 820 Proton acceptor (By similarity).
Amino Acid Sequence for BAME1_ARATH » Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1
MKLFLLLLFL LHISHTFTAS RPISEFRALL SLKTSLTGAG DDKNSPLSSW KVSTSFCTWI GVTCDVSRRH VTSLDLSGLN LSGTLSPDVS HLRLLQNLSL AENLISGPIP PEISSLSGLR HLNLSNNVFN GSFPDEISSG LVNLRVLDVY NNNLTGDLPV SVTNLTQLRH LHLGGNYFAG KIPPSYGSWP VIEYLAVSGN ELVGKIPPEI GNLTTLRELY IGYYNAFEDG LPPEIGNLSE LVRFDGANCG LTGEIPPEIG KLQKLDTLFL QVNVFSGPLT WELGTLSSLK SMDLSNNMFT GEIPASFAEL KNLTLLNLFR NKLHGEIPEF IGDLPELEVL QLWENNFTGS IPQKLGENGK LNLVDLSSNK LTGTLPPNMC SGNKLETLIT LGNFLFGSIP DSLGKCESLT RIRMGENFLN GSIPKGLFGL PKLTQVELQD NYLSGELPVA GGVSVNLGQI SLSNNQLSGP LPPAIGNFTG VQKLLLDGNK FQGPIPSEVG KLQQLSKIDF SHNLFSGRIA PEISRCKLLT FVDLSRNELS GEIPNEITAM KILNYLNLSR NHLVGSIPGS ISSMQSLTSL DFSYNNLSGL VPGTGQFSYF NYTSFLGNPD LCGPYLGPCK DGVAKGGHQS HSKGPLSASM KLLLVLGLLV CSIAFAVVAI IKARSLKKAS ESRAWRLTAF QRLDFTCDDV LDSLKEDNII GKGGAGIVYK GVMPNGDLVA VKRLAAMSRG SSHDHGFNAE IQTLGRIRHR HIVRLLGFCS NHETNLLVYE YMPNGSLGEV LHGKKGGHLH WDTRYKIALE AAKGLCYLHH DCSPLIVHRD VKSNNILLDS NFEAHVADFG LAKFLQDSGT SECMSAIAGS YGYIAPEYAY TLKVDEKSDV YSFGVVLLEL VTGRKPVGEF GDGVDIVQWV RKMTDSNKDS VLKVLDPRLS SIPIHEVTHV FYVAMLCVEE QAVERPTMRE VVQILTEIPK LPPSKDQPMT ESAPESELSP KSGVQSPPDL LNL