BAMBI_HUMAN » BMP and activin membrane-bound inhibitor homolog

BAMBI_HUMAN » BMP and activin membrane-bound inhibitor homolog
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
BAMBI_HUMAN » BMP and activin membrane-bound inhibitor homolog » Non-metastatic gene A protein;Putative transmembrane protein NMA;
Hydrophobic Thickness 37.6 ± 4.4 Å
Tilt Angle 16 ± 6°
ΔGtransfer -33.8 kcal/mol
ΔGfold -22.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 148-176 (145-178)
Pathways

Signal Transduction (Reactome)

TGF-beta signaling pathway (KEGG)

Wnt signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

ACV1B, Complex: ACV1B:BAMBI, PubMed

ACVL1, Complex: ACVL1:BAMBI, PubMed

ACVR1, Complex: ACVR1:BAMBI, PubMed

BMR1A, Complex: BMR1A:BAMBI, PubMed

BMR1B, Complex: BMR1B:BAMBI, PubMed

LRP6, Complex: BAMBI:LRP6, PubMed

TGFR1, Complex: BAMBI:TGFR1, PubMed

Domains

AA: 4-111, BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain

UniProt annotation for BAMBI_HUMAN » BMP and activin membrane-bound inhibitor homolog
FUNCTION: Negatively regulates TGF-beta signaling.

TISSUE SPECIFICITY: High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

DEVELOPMENTAL STAGE: Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.

UniProt features for BAMBI_HUMAN » BMP and activin membrane-bound inhibitor homolog
SIGNAL 1 20
CHAIN 21 260 BMP and activin membrane-bound inhibitor homolog.
Amino Acid Sequence for BAMBI_HUMAN » BMP and activin membrane-bound inhibitor homolog
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND KILSLVHWGM YSGHGKLEFV