AVR2A_HUMAN » Activin receptor type-2A

AVR2A_HUMAN » Activin receptor type-2A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
AVR2A_HUMAN » Activin receptor type-2A » Activin receptor type IIA;ACTR-IIA; ACTRIIA;
Hydrophobic Thickness 34.4 ± 2.6 Å
Tilt Angle 4 ± 9°
ΔGtransfer -26.0 kcal/mol
ΔGfold -20.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 139-162 (135-167)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Developmental Biology (Reactome)

Signal Transduction (Reactome)

TGF-beta signaling pathway (KEGG)

PDB 3q4t (191-488), 3soc (191-488), 4asx (191-488)
OPM none
Complexes

AVR2A:AVR2B:INHBA_RAT

AVR2A:BMR1A:BMP2_MOUSE

Interactions

ACV1B, Complex: AVR2A:ACV1B, PubMed

ACVL1, Complex: ACVL1:AVR2A, PubMed

ACVR1, Complex: AVR2B:ACVR1:AVR2A, PubMed

AVR2B, Complex: AVR2A:AVR2B, PDBID: 1nys, PubMed

BMR1A, Complex: AVR2A:BMR1A, PDBID: 2goo

EGLN, Complex: EGLN:AVR2A, PubMed

PLS1, Complex: PLS1:AVR2A, PubMed

SYJ2B, Complex: RBP1:REPS2:SYJ2B:AVR2A, PubMed

TGBR3, Complex: AVR2A:TGBR3:INHA, PubMed

TGBR3, Complex: TGBR3:AVR2A, PubMed

Domains

AA: 27-114, PDBID: 1BTE, Subunit A, Seq Identity:66%, Activin types I and II receptor domain

AA: 196-481, PDBID: 3Q4T, Subunit B, Seq Identity:100%, Protein kinase domain

UniProt annotation for AVR2A_HUMAN » Activin receptor type-2A
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor- protein] phosphate.

SUBUNIT: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).

UniProt features for AVR2A_HUMAN » Activin receptor type-2A
SIGNAL 1 19 Potential.
CHAIN 20 513 Activin receptor type-2A.
DOMAIN 192 485 Protein kinase.
ACT_SITE 322 322 Proton acceptor (By similarity).
DISULFID 30 60 By similarity.
DISULFID 50 78 By similarity.
DISULFID 85 104 By similarity.
DISULFID 91 103 By similarity.
DISULFID 105 110 By similarity.
Amino Acid Sequence for AVR2A_HUMAN » Activin receptor type-2A
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL