AUP1_HUMAN » Ancient ubiquitous protein 1

AUP1_HUMAN » Ancient ubiquitous protein 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
AUP1_HUMAN » Ancient ubiquitous protein 1 »
Hydrophobic Thickness 27.6 ± 5.2 Å
Tilt Angle 50 ± 0°
ΔGtransfer -26.8 kcal/mol
ΔGfold -14.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 22-51 (21-55)
Pathways none
PDB 2ekf (358-411)
OPM none
Complexes none
Interactions

ITA1, Complex: AUP1:ITA1, PubMed

ITA2B, Complex: AUP1:ITA2B, PubMed

ITA2, Complex: AUP1:ITA2, PubMed

ITA5, Complex: AUP1:ITA5, PubMed

ITAM, Complex: ITAM:AUP1, PubMed

ITAV, Complex: ITAV:AUP1, PubMed

OST48, Complex: OST48:AUP1, PubMed

PCAT1, Complex: PCAT1:AUP1, PubMed

SE1L1, Complex: UB2J1:SE1L1:FAF2:AUP1:OS9, PubMed

SPTC1, Complex: SPTC1:AUP1, PubMed

UB2J1, Complex: UB2J1:AUP1, PubMed

Domains

AA: 365-403, PDBID: 2EKF, Subunit A, Seq Identity:100%, CUE domain

UniProt annotation for AUP1_HUMAN » Ancient ubiquitous protein 1
FUNCTION: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

SUBUNIT: Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.

TISSUE SPECIFICITY: Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.

UniProt features for AUP1_HUMAN » Ancient ubiquitous protein 1
CHAIN 1 476 Ancient ubiquitous protein 1.
DOMAIN 362 404 CUE.
Amino Acid Sequence for AUP1_HUMAN » Ancient ubiquitous protein 1
MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF LVSCALPDSV LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTVSESEAE SATGRFPGAQ LKAPLSPLAF RMEDTEALPL TPILYPTCQF FFFIFLNIFL LAFSSPGSQP LLNSPPSFVC WSRGFMEMNG RGELVESLKR FCASTRLPPT PLLLFPEEEA TNGREGLLRF SSWPFSIQDV VQPLTLQVQR PLVSVTVSDA SWVSELLWSL FVPFTVYQVR WLRPVHRQLG EANEEFALRV QQLVAKELGQ TGTRLTPADK AEHMKRQRHP RLRPQSAQSS FPPSPGPSPD VQLATLAQRV KEVLPHVPLG VIQRDLAKTG CVDLTITNLL EGAVAFMPED ITKGTQSLPT ASASKFPSSG PVTPQPTALT FAKSSWARQE SLQERKQALY EYARRRFTER RAQEAD