ATRN_HUMAN » Attractin

ATRN_HUMAN » Attractin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ATRN_HUMAN » Attractin » DPPT-L;Mahogany homolog;
Hydrophobic Thickness 35.2 ± 1.0 Å
Tilt Angle 1 ± 2°
ΔGtransfer -55.3 kcal/mol
ΔGfold -22.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1279-1304 (1277-1306)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 132-245, PDBID: 3KQ4, Subunit B, Seq Identity:31%, CUB domain

AA: 340-384, PDBID: 4ZGC, Subunit B, Seq Identity:30%, Kelch motif

AA: 391-440, Kelch motif

AA: 554-606, PDBID: 2UVK, Subunit B, Seq Identity:27%, Kelch motif

AA: 805-920, PDBID: 3FF7, Subunit C, Seq Identity:26%, Lectin C-type domain

AA: 932-983, PDBID: 1OLZ, Subunit B, Seq Identity:25%, Plexin repeat

AA: 986-1061, PDBID: 3NVN, Subunit B, Seq Identity:22%, Plexin repeat

UniProt annotation for ATRN_HUMAN » Attractin
FUNCTION: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).

SUBUNIT: Monomer and homotrimer.

TISSUE SPECIFICITY: Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.

INDUCTION: Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.

UniProt features for ATRN_HUMAN » Attractin
SIGNAL 1 28 Potential.
PROPEP 29 83 Probable.
CHAIN 84 1429 Attractin.
DOMAIN 101 129 EGF-like.
DOMAIN 132 248 CUB.
REPEAT 352 402 Kelch 1.
REPEAT 404 451 Kelch 2.
REPEAT 461 508 Kelch 3.
REPEAT 513 564 Kelch 4.
REPEAT 566 624 Kelch 5.
REPEAT 625 671 Kelch 6.
DOMAIN 703 748 PSI 1.
DOMAIN 755 794 PSI 2.
DOMAIN 795 919 C-type lectin.
DOMAIN 932 983 PSI 3.
DOMAIN 986 1061 PSI 4.
DOMAIN 1063 1108 Laminin EGF-like 1.
DOMAIN 1109 1157 Laminin EGF-like 2.
DISULFID 101 111 By similarity.
DISULFID 105 118 By similarity.
DISULFID 120 129 By similarity.
DISULFID 250 260 By similarity.
DISULFID 254 271 By similarity.
DISULFID 273 282 By similarity.
DISULFID 816 918 By similarity.
DISULFID 1063 1071 By similarity.
DISULFID 1065 1077 By similarity.
DISULFID 1080 1089 By similarity.
DISULFID 1092 1106 By similarity.
DISULFID 1127 1137 By similarity.
DISULFID 1140 1155 By similarity.
Amino Acid Sequence for ATRN_HUMAN » Attractin
MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV WKIKQSCWAS RRREQLLREM QQMASRPFAS VNVALETDEE PPDLIGGSIK TVPKPIALEP CFGNKAAVLS VFVRLPRGLG GIPPPGQSGL AVASALVDIS QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI