ATRN1_HUMAN » Attractin-like protein 1

ATRN1_HUMAN » Attractin-like protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ATRN1_HUMAN » Attractin-like protein 1 »
Hydrophobic Thickness 35.2 ± 4.6 Å
Tilt Angle 30 ± 8°
ΔGtransfer -26.2 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1230-1255 (1228-1257)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 93-206, PDBID: 3KQ4, Subunit B, Seq Identity:31%, CUB domain

AA: 249-280, PDBID: 4Z80, Subunit A, Seq Identity:43%, EGF-like domain

AA: 351-393, Kelch motif

AA: 466-518, Galactose oxidase, central domain

AA: 520-574, PDBID: 3II7, Subunit A, Seq Identity:25%, Kelch motif

AA: 579-614, Kelch motif

AA: 765-874, PDBID: 1LIT, Subunit A, Seq Identity:28%, Lectin C-type domain

AA: 889-939, PDBID: 1SHY, Subunit B, Seq Identity:30%, Plexin repeat

AA: 942-1012, PDBID: 3AL8, Subunit B, Seq Identity:21%, Plexin repeat

UniProt annotation for ATRN1_HUMAN » Attractin-like protein 1
FUNCTION: May play a role in melanocortin signaling pathways that regulate energy homeostasis.

SUBUNIT: Interacts with MC4R.

UniProt features for ATRN1_HUMAN » Attractin-like protein 1
SIGNAL 1 52 Potential.
CHAIN 53 1379 Attractin-like protein 1.
DOMAIN 53 91 EGF-like 1.
DOMAIN 93 209 CUB.
DOMAIN 207 245 EGF-like 2.
REPEAT 316 365 Kelch 1.
REPEAT 367 415 Kelch 2.
REPEAT 427 475 Kelch 3.
REPEAT 480 531 Kelch 4.
REPEAT 533 591 Kelch 5.
REPEAT 592 638 Kelch 6.
DOMAIN 614 657 PSI 1.
DOMAIN 666 709 PSI 2.
DOMAIN 715 760 PSI 3.
DOMAIN 755 873 C-type lectin.
DOMAIN 889 939 PSI 4.
DOMAIN 942 1012 PSI 5.
DOMAIN 1014 1059 Laminin EGF-like 1.
DOMAIN 1060 1108 Laminin EGF-like 2.
DISULFID 63 79 By similarity.
DISULFID 81 90 By similarity.
DISULFID 93 119 By similarity.
DISULFID 211 221 By similarity.
DISULFID 215 233 By similarity.
DISULFID 235 244 By similarity.
DISULFID 776 872 By similarity.
DISULFID 1014 1022 By similarity.
DISULFID 1016 1028 By similarity.
DISULFID 1031 1040 By similarity.
DISULFID 1043 1057 By similarity.
DISULFID 1060 1069 By similarity.
DISULFID 1062 1076 By similarity.
DISULFID 1078 1088 By similarity.
DISULFID 1091 1106 By similarity.
Amino Acid Sequence for ATRN1_HUMAN » Attractin-like protein 1
METGGRARTG TPQPAAPGVW RARPAGGGGG GASSWLLDGN SWLLCYGFLY LALYAQVSQS KPCERTGSCF SGRCVNSTCL CDPGWVGDQC QHCQGRFKLT EPSGYLTDGP INYKYKTKCT WLIEGYPNAV LRLRFNHFAT ECSWDHMYVY DGDSIYAPLI AVLSGLIVPE IRGNETVPEV VTTSGYALLH FFSDAAYNLT GFNIFYSINS CPNNCSGHGK CTTSVSVPSQ VYCECDKYWK GEACDIPYCK ANCGSPDHGY CDLTGEKLCV CNDSWQGPDC SLNVPSTESY WILPNVKPFS PSVGRASHKA VLHGKFMWVI GGYTFNYSSF QMVLNYNLES SIWNVGTPSR GPLQRYGHSL ALYQENIFMY GGRIETNDGN VTDELWVFNI HSQSWSTKTP TVLGHGQQYA VEGHSAHIME LDSRDVVMII IFGYSAIYGY TSSIQEYHIS SNTWLVPETK GAIVQGGYGH TSVYDEITKS IYVHGGYKAL PGNKYGLVDD LYKYEVNTKT WTILKESGFA RYLHSAVLIN GAMLIFGGNT HNDTSLSNGA KCFSADFLAY DIACDEWKIL PKPNLHRDVN RFGHSAVVIN GSMYIFGGFS SVLLNDILVY KPPNCKAFRD EELCKNAGPG IKCVWNKNHC ESWESGNTNN ILRAKCPPKT AASDDRCYRY ADCASCTANT NGCQWCDDKK CISANSNCSM SVKNYTKCHV RNEQICNKLT SCKSCSLNLN CQWDQRQQEC QALPAHLCGE GWSHIGDACL RVNSSRENYD NAKLYCYNLS GNLASLTTSK EVEFVLDEIQ KYTQQKVSPW VGLRKINISY WGWEDMSPFT NTTLQWLPGE PNDSGFCAYL ERAAVAGLKA NPCTSMANGL VCEKPVVSPN QNARPCKKPC SLRTSCSNCT SNGMECMWCS STKRCVDSNA YIISFPYGQC LEWQTATCSP QNCSGLRTCG QCLEQPGCGW CNDPSNTGRG HCIEGSSRGP MKLIGMHHSE MVLDTNLCPK EKNYEWSFIQ CPACQCNGHS TCINNNVCEQ CKNLTTGKQC QDCMPGYYGD PTNGGQCTAC TCSGHANICH LHTGKCFCTT KGIKGDQCQL CDSENRYVGN PLRGTCYYSL LIDYQFTFSL LQEDDRHHTA INFIANPEQS NKNLDISINA SNNFNLNITW SVGSTAGTIS GEETSIVSKN NIKEYRDSFS YEKFNFRSNP NITFYVYVSN FSWPIKIQIA FSQHNTIMDL VQFFVTFFSC FLSLLLVAAV VWKIKQTCWA SRRREQLLRE RQQMASRPFA SVDVALEVGA EQTEFLRGPL EGAPKPIAIE PCAGNRAAVL TVFLCLPRGS SGAPPPGQSG LAIASALIDI SQQKASDSKD KTSGVRNRKH LSTRQGTCV