ATG27_YEAST » Autophagy-related protein 27

ATG27_YEAST » Autophagy-related protein 27
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
ATG27_YEAST » Autophagy-related protein 27 » Enhancer of VPS34 missorting protein 1;
Hydrophobic Thickness 33.6 ± 2.6 Å
Tilt Angle 8 ± 5°
ΔGtransfer -40.1 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 199-221 (197-224)
Pathways none
PDB none
OPM none
Complexes none
Interactions

EMP47, Complex: EMP47:ATG27, PubMed

OST1, Complex: OST1:ATG27, PubMed

PMP2, Complex: PMP2:ATG27, PubMed

SAC1, Complex: SAC1:ATG27, PubMed

SED5, Complex: SED5:ATG27, PubMed

TLG2, Complex: TLG2:ATG27, PubMed

VOA1, Complex: ATG27:VOA1

VPS10, Complex: VPS10:ATG27, PubMed

YD19A, Complex: YD19A:ATG27, PubMed

Domains

AA: 6-267, Autophagy-related protein 27

UniProt annotation for ATG27_YEAST » Autophagy-related protein 27
FUNCTION: Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9.

SUBUNIT: Forms a complex with ATG9 and ATG23.

MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium.

UniProt features for ATG27_YEAST » Autophagy-related protein 27
SIGNAL 1 19 Potential.
CHAIN 20 271 Autophagy-related protein 27.
Amino Acid Sequence for ATG27_YEAST » Autophagy-related protein 27
MVSKTWICGF ISIITVVQAL SCEKHDVLKK YQVGKFSSLT STERDTPPST TIEKWWINVC EEHNVEPPEE CKKNDMLCGL TDVILPGKDA ITTQIIDFDK NIGFNVEETE SALTLTLKGA TWGANSFDAK LEFQCNDNMK QDELTSHTWA DKSIQLTLKG PSGCLKSKDD DKKNGDGDNG KDGDSEGKKP AKKAGGTSWF TWLFLYALLF TLIYLMVVSF LNTRGGSFQD FRAEFIQRST QFLTSLPEFC KEVVSRILGR STAQRGGYSA V