ATD3A_HUMAN » ATPase family AAA domain-containing protein 3A

ATD3A_HUMAN » ATPase family AAA domain-containing protein 3A
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
ATD3A_HUMAN » ATPase family AAA domain-containing protein 3A »
Hydrophobic Thickness 29.2 ± 2.4 Å
Tilt Angle 6 ± 5°
ΔGtransfer -15.3 kcal/mol
ΔGfold -8.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 292-312 (291-313)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ERBB2, Complex: ATD3A:ERBB2, PubMed

ESR1, Complex: ESR1:ATD3A, PubMed

ITA4, Complex: ITA4:ATD3A, PubMed

LMTK1, Complex: ATD3A:LMTK1

TNR1A, Complex: TNR1A:ATD3A, PubMed

TNR1B, Complex: TNR1B:ATD3A, PubMed

VCAM1, Complex: ATD3A:VCAM1, PubMed

Domains

AA: 27-104, Domain of unknown function (DUF3523)

AA: 131-334, Domain of unknown function (DUF3523)

AA: 396-523, PDBID: 4CR2, Subunit H, Seq Identity:36%, ATPase family associated with various cellular activities (AAA)

UniProt annotation for ATD3A_HUMAN » ATPase family AAA domain-containing protein 3A
FUNCTION: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis.

SUBUNIT: Can form homooligomers. Homodimer formation at the N- terminus may be regulated by ATP and is required for the interaction with the inner surface of the mitochondrial outer membrane and correct mitochondrial homeostasis. Interacts with components of the mitochondrial ribosome and with other proteins involved in mitochondrial RNA metabolism. May also interact with protein involved in lipid metabolism, including STARD9. May interact with FAM210A. Interacts with GADD45GIP1. Interacts with S100B in a Ca(+2)- and Zn(+2)-dependent manner; this interaction probably occurs in the cytosol prior to mitochondrial targeting. S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. Interacts with HSP60/HSPD1. Forms heterooligomers with ATAD3B; this interaction may affect ATAD3A activity.

TISSUE SPECIFICITY: Overexpressed in lung adenocarcinomas (at protein level).

INDUCTION: Up-regulated by Angiotensin/AGT.

DOMAIN: The transmembrane domain and a C-terminal adjacent region contain all information necessary for mitochondrial targeting.

UniProt features for ATD3A_HUMAN » ATPase family AAA domain-containing protein 3A
CHAIN 2 634 ATPase family AAA domain-containing protein 3A.
REGION 2 50 Required for interaction with the inner surface of the mitochondrial outer membrane.
REGION 338 353 S100B-binding.
COILED 139 267 Potential.
Amino Acid Sequence for ATD3A_HUMAN » ATPase family AAA domain-containing protein 3A
MSWLFGINKG PKGEGAGPPP PLPPAQPGAE GGGDRGLGDR PAPKDKWSNF DPTGLERAAK AARELEHSRY AKDALNLAQM QEQTLQLEQQ SKLKMRLEAL SLLHTLVWAW SLCRAGAVQT QERLSGSASP EQVPAGECCA LQEYEAAVEQ LKSEQIRAQA EERRKTLSEE TRQHQARAQY QDKLARQRYE DQLKQQQLLN EENLRKQEES VQKQEAMRRA TVEREMELRH KNEMLRVEAE ARARAKAERE NADIIREQIR LKAAEHRQTV LESIRTAGTL FGEGFRAFVT DWDKVTATVA GLTLLAVGVY SAKNATLVAG RFIEARLGKP SLVRETSRIT VLEALRHPIQ VSRRLLSRPQ DALEGVVLSP SLEARVRDIA IATRNTKKNR SLYRNILMYG PPGTGKTLFA KKLALHSGMD YAIMTGGDVA PMGREGVTAM HKLFDWANTS RRGLLLFVDE ADAFLRKRAT EKISEDLRAT LNAFLYRTGQ HSNKFMLVLA SNQPEQFDWA INDRINEMVH FDLPGQEERE RLVRMYFDKY VLKPATEGKQ RLKLAQFDYG RKCSEVARLT EGMSGREIAQ LAVSWQATAY ASEDGVLTEA MMDTRVQDAV QQHQQKMCWL KAEGPGRGDE PSPS