ASGR2_HUMAN » Asialoglycoprotein receptor 2

ASGR2_HUMAN » Asialoglycoprotein receptor 2
Magnify ASGR2_HUMAN » Asialoglycoprotein receptor 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ASGR2_HUMAN » Asialoglycoprotein receptor 2 » ASGP-R 2; ASGPR 2; C-type lectin domain family 4 member H2;Hepatic lectin H2;HL-2;
Hydrophobic Thickness 34.4 ± 5.2 Å
Tilt Angle 38 ± 1°
ΔGtransfer -23.4 kcal/mol
ΔGfold -14.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 49-78 (49-80)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ASGR1, Complex: ASGR1:ASGR2, PubMed

EDEM1, Complex: ASGR2:EDEM1, PubMed

Domains

AA: 29-167, Hepatic lectin, N-terminal domain

AA: 194-302, PDBID: 1DV8, Subunit A, Seq Identity:67%, Lectin C-type domain

UniProt annotation for ASGR2_HUMAN » Asialoglycoprotein receptor 2
FUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

SUBUNIT: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.

TISSUE SPECIFICITY: Expressed exclusively in hepatic parenchymal cells.

MISCELLANEOUS: Calcium is required for ligand binding.

UniProt features for ASGR2_HUMAN » Asialoglycoprotein receptor 2
CHAIN 1 311 Asialoglycoprotein receptor 2.
DOMAIN 176 302 C-type lectin.
MOTIF 5 8 Endocytosis signal (Potential).
DISULFID 177 188 By similarity.
DISULFID 205 300 By similarity.
DISULFID 278 292 By similarity.
Amino Acid Sequence for ASGR2_HUMAN » Asialoglycoprotein receptor 2
MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA QRLCSMVCFS LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF SNFSSSTLTE VQAISTHGGS VGDKITSLGA KLEKQQQDLK ADHDALLFHL KHFPVDLRFV ACQMELLHSN GSQRTCCPVN WVEHQGSCYW FSHSGKAWAE AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS DGSWKWVDGT DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC EKRRNATGEV A