ASGR1_HUMAN » Asialoglycoprotein receptor 1

ASGR1_HUMAN » Asialoglycoprotein receptor 1
Magnify ASGR1_HUMAN » Asialoglycoprotein receptor 1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ASGR1_HUMAN » Asialoglycoprotein receptor 1 » ASGP-R 1; ASGPR 1; C-type lectin domain family 4 member H1;Hepatic lectin H1;HL-1;
Hydrophobic Thickness 33.2 ± 2.4 Å
Tilt Angle 1 ± 2°
ΔGtransfer -22.5 kcal/mol
ΔGfold -15.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 38-60 (37-62)
Pathways none
PDB 1dv8 (154-281)
OPM none
Complexes none
Interactions

A4, Complex: ASGR1:A4, PubMed

ASGR2, Complex: ASGR1:ASGR2, PubMed

CALX, Complex: ASGR1:CALX, PubMed

CLC4G, Complex: CLC4G:ASGR1, PubMed

EDEM1, Complex: ASGR1:EDEM1, PubMed

ITA1, Complex: ITA1:ASGR1, PubMed

Domains

AA: 13-144, Hepatic lectin, N-terminal domain

AA: 171-279, PDBID: 1DV8, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for ASGR1_HUMAN » Asialoglycoprotein receptor 1
FUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

SUBUNIT: Interacts with LASS2.

TISSUE SPECIFICITY: Expressed exclusively in hepatic parenchymal cells.

MISCELLANEOUS: Calcium is required for ligand binding.

UniProt features for ASGR1_HUMAN » Asialoglycoprotein receptor 1
CHAIN 2 291 Asialoglycoprotein receptor 1.
DOMAIN 161 278 C-type lectin.
COILED 61 123 Potential.
MOTIF 5 8 Endocytosis signal (Potential).
DISULFID 154 165
DISULFID 182 277
DISULFID 255 269
Amino Acid Sequence for ASGR1_HUMAN » Asialoglycoprotein receptor 1
MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL LLLVVVCVIG SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR KMKSLESQLE KQQKDLSEDH SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE RTCCPVNWVE HERSCYWFSR SGKAWADADN YCRLEDAHLV VVTSWEEQKF VQHHIGPVNT WMGLHDQNGP WKWVDGTDYE TGFKNWRPEQ PDDWYGHGLG GGEDCAHFTD DGRWNDDVCQ RPYRWVCETE LDKASQEPPL L