AREG_HUMAN » Amphiregulin

AREG_HUMAN » Amphiregulin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
AREG_HUMAN » Amphiregulin » AR; Colorectum cell-derived growth factor;CRDGF;
Hydrophobic Thickness 40.4 ± 3.8 Å
Tilt Angle 8 ± 5°
ΔGtransfer -28.1 kcal/mol
ΔGfold -26.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 196-223 (193-229)
Pathways

ErbB signaling pathway (KEGG)

Hippo signaling pathway (KEGG)

PDB 2rnl (142-184)
OPM none
Complexes none
Interactions

A4, Complex: AREG:A4, PubMed

EGFR, Complex: AREG:EGFR, PubMed

Domains none
UniProt annotation for AREG_HUMAN » Amphiregulin
FUNCTION: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

SUBUNIT: The immature precursor interacts with CNIH.

INDUCTION: By phorbol 12-myristate 13-acetate (PMA).

MISCELLANEOUS: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.

UniProt features for AREG_HUMAN » Amphiregulin
SIGNAL 1 19 Potential.
PROPEP 20 100
CHAIN 101 184 Amphiregulin.
PROPEP 185 252
DOMAIN 142 182 EGF-like.
DISULFID 146 159 By similarity.
DISULFID 154 170 By similarity.
DISULFID 172 181 By similarity.
Amino Acid Sequence for AREG_HUMAN » Amphiregulin
MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK LRQENGNVHA IA