ARAID_HUMAN » All-trans retinoic acid-induced differentiation factor

ARAID_HUMAN » All-trans retinoic acid-induced differentiation factor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ARAID_HUMAN » All-trans retinoic acid-induced differentiation factor » Apoptosis-related protein 3;APR-3; p18;
Hydrophobic Thickness 34.4 ± 1.8 Å
Tilt Angle 10 ± 8°
ΔGtransfer -24.1 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 198-221 (197-226)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:ARAID, PubMed

Domains none
UniProt annotation for ARAID_HUMAN » All-trans retinoic acid-induced differentiation factor
FUNCTION: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.

SUBUNIT: Interacts with NELL1; the interaction promotes osteoblastic differentiation and mineralization.

TISSUE SPECIFICITY: Weakly expressed in hematopoietic cell lines.

INDUCTION: Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines.

UniProt features for ARAID_HUMAN » All-trans retinoic acid-induced differentiation factor
SIGNAL 1 30
CHAIN 31 229 All-trans retinoic acid-induced differentiation factor.
DOMAIN 152 193 EGF-like.
DISULFID 156 171 By similarity.
DISULFID 165 181 By similarity.
DISULFID 183 192 By similarity.
Amino Acid Sequence for ARAID_HUMAN » All-trans retinoic acid-induced differentiation factor
MAPHDPGSLT TLVPWAAALL LALGVERALA LPEICTQCPG SVQNLSKVAF YCKTTRELML HARCCLNQKG TILGLDLQNC SLEDPGPNFH QAHTTVIIDL QANPLKGDLA NTFRGFTQLQ TLILPQHVNC PGGINAWNTI TSYIDNQICQ GQKNLCNNTG DPEMCPENGS CVPDGPGLLQ CVCADGFHGY KCMRQGSFSL LMFFGILGAT TLSVSILLWA TQRRKAKTS